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Cholinergic regulation of decision making under risk of punishment.
Neurobiol Learn Mem
December 2024
Department of Psychology, The University of Texas at Austin, Austin TX 78712, United States; Department of Neurology, The University of Texas at Austin, Austin TX 78712, United States; Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin TX 78712, United States. Electronic address:
The ability to choose between options that differ in their risks and rewards depends on brain regions within the mesocorticolimbic circuit and regulation of their activity by neurotransmitter systems. Dopamine neurotransmission in particular plays a critical role in modulating such risk-taking behavior; however, the contribution of other major modulatory neurotransmitters, such as acetylcholine, is not as well-defined, especially for decision making in which the risk associated with more rewarding outcomes involves adverse consequences. Consequently, the goal of the current experiments was to examine how cholinergic signaling influences decision making involving risk of explicit punishment.
View Article and Find Full Text PDFEffects of oxotremorine on convulsions in mice induced by scopolamine and food intake after fasting.
Behav Brain Res
March 2025
Department of Medical Pharmacology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address:
Antimuscarinic administration and food intake cause convulsions in mice and rats after fasting for 48 h or less. Increased M and M muscarinic receptor expression in brain regions during fasting, and reversal of changes by refeeding may contribute to these seizures. Since receptor expression is regulated in response to agonist stimulation, this study investigated effects of nonselective muscarinic receptor agonist oxotremorine on convulsions in fasted animals.
View Article and Find Full Text PDFNicotine promotes the utility of short-term memory during visual search in macaque monkeys.
Psychopharmacology (Berl)
September 2022
Department of Physiology, Hokkaido University School of Medicine, Sapporo, 060-8638, Japan.
Rationale: The central cholinergic system is a major therapeutic target for restoring cognitive functions. Although manipulation of cholinergic signaling is known to alter working memory (WM), the underlying mechanism remains unclear. It is widely accepted that WM consists of multiple functional modules, one storing short-term memory and the other manipulating and utilizing it.
View Article and Find Full Text PDFMoxibustion attenuates neurogenic detrusor overactivity in spinal cord injury rats by inhibiting M2/ATP/P2X3 pathway.
Brain Res
August 2022
International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
Purpose: Activation of muscarinic receptors located in bladder sensory pathways is generally considered to be the primary contributor for driving the pathogenesis of neurogenic detrusor overactivity following spinal cord injury. The present study is undertaken to examine whether moxibustion improves neurogenic detrusor overactivity via modulating the abnormal muscarinic receptor pathway.
Materials And Methods: Female Sprague-Dawley rats were subjected to spinal cord injury with T9-10 spinal cord transection.
Pharmacological and molecular characterization of the A-type muscarinic acetylcholine receptor from Anopheles gambiae.
Insect Mol Biol
August 2022
Univ Angers, INRAE, SiFCIR Laboratory, SFR QUASAV, F-49000 Angers, France.
Muscarinic acetylcholine receptors (mAChRs) which are G protein-coupled receptors play key roles in insect physiology. Whereas vertebrate mAChRs are important targets for pharmaceutical drugs, insect mAChRs are under-exploited by the agro-chemical industry. Moreover, insect mAChRs have been less well studied than their vertebrate counterparts.
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