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Comparison of Lineblot and Immunoprecipitation Methods in the Detection of Myositis-Specific and Myositis-Associated Antibodies in Patients with Idiopathic Inflammatory Myopathies: Consistency with Clinical Diagnoses.
Diagnostics (Basel)
September 2024
Rheumatology and Clinical Immunology Unit, ERN ReCONNET Centre, ASST Spedali Civili, Piazzale Spedali Civili, 1, 25124 Brescia, Italy.
Article Synopsis
- * A total of 69 patients were analyzed, showing high concordance for certain antibodies (like anti-Ku and anti-PM/Scl) and moderate agreement for others (like anti-Jo1 and anti-Mi-2), while some antibodies could only be detected by one method.
- * The results suggest that LB may be more sensitive for detecting multiple MSAs and specific antibodies, while IP performs well for dermatomyositis-associated MSAs
Pathogenic mechanisms of disease in idiopathic inflammatory myopathies: autoantibodies as clues.
Front Immunol
September 2024
Jiangxi Province Key Laboratory of Immunity and Inflammation, Jiangxi Provincial People's Hospital, Nanchang, China.
Idiopathic inflammatory myopathies (IIMs) encompass a spectrum of autoimmune diseases characterized by muscle inflammation and systemic involvement. This review aimed to synthesize current evidence on the clinical significance and pathogenic mechanisms underlying autoantibodies associated with IIMs. Autoantibodies targeting aminoacyl-tRNA synthetases (ARS) play a pivotal role in antisynthetase syndrome (ASS), highlighting associations with interstitial lung disease (ILD) and distinctive clinical features.
View Article and Find Full Text PDFThe Autoantibody Array Assay: A Novel Autoantibody Detection Method.
Diagnostics (Basel)
September 2023
Department of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan.
Systemic sclerosis (SSc) and dermatomyositis (DM) are autoimmune collagen diseases. Specific autoantibodies are known to be involved in their pathogeneses, each presenting with a different clinical manifestation. Although immunoprecipitation is the gold standard method for detecting autoantibodies, it is difficult to perform in all cases owing to the use of radioisotopes.
View Article and Find Full Text PDFAssociation Between HLA Alleles and Autoantibodies in Dermatomyositis Defined by Sarcoplasmic Expression of Myxovirus Resistance Protein A.
J Rheumatol
September 2023
M. Oyama, MD, PhD, Shigeaki Suzuki, MD, PhD, Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
Objective: The diagnosis in the studies analyzing HLA of dermatomyositis (DM) was based on a combined clinical category of polymyositis/DM. This retrospective study investigated the associations of HLA with 5 DM-specific autoantibodies in Japanese patients diagnosed by muscle pathology.
Methods: We diagnosed Japanese patients with DM based on sarcoplasmic expression of myxovirus resistance protein A.
Narrative review of autoantibodies in idiopathic inflammatory myopathies.
Ann Transl Med
April 2023
Department of Neurology at Peking University First Hospital, Beijing, China.
Objective: To discuss the characteristics of autoantigens, detection methods and roles of myositis associated autoantibodies (MAAs) and myositis specific autoantibodies (MSAs), as well as the clinical features of disease subgroups defined by MAAs/MSAs.
Background: Autoantibodies in patients with idiopathic inflammatory myopathies (IIMs) are conventionally divided into MAAs and MSAs. MAAs usually refer to autoantibodies which are also available in systematic autoimmune diseases (anti-PM/SCL, anti-Ku, anti-Ro52 and anti-U1RNP antibodies).
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