Practical Synthesis of Ethynyl(phenyl)-λ-Iodane Using Calcium Carbide as an Ethynyl Group Source. | LitMetric

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Practical Synthesis of Ethynyl(phenyl)-λ-Iodane Using Calcium Carbide as an Ethynyl Group Source. | LitMetric

Practical Synthesis of Ethynyl(phenyl)-λ-Iodane Using Calcium Carbide as an Ethynyl Group Source.

Takahiro Hashishin Taisei Osawa Kazunori Miyamoto Masanobu Uchiyama

Front Chem

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

Published: February 2020

- This process involves stannylating calcium carbide and then performing a Sn-hypervalent iodine(III) exchange reaction.
- The outcome is the creation of an electrophilic ethynylating agent called ethynyl(phenyl)-λ-iodane, produced in high yield.
- It is cost-effective, using inexpensive materials, and can be carried out easily without the need for special precautions.

Stannylation of calcium carbide followed by Sn-hypervalent iodine(III) exchange reaction cleanly afforded the electrophilic ethynylating agent ethynyl(phenyl)-λ-iodane in high yield. This two-step method uses very inexpensive materials and is readily operable without any special precautions.

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010717	PMC
http://dx.doi.org/10.3389/fchem.2020.00012	DOI Listing

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