Radon (Rn), thoron (Tn), and thoron progeny (TnP) were measured in seven inhabited areas of the uranium and thorium bearing region of Lolodorf, located in southwestern Cameroon. Then the equilibrium factor (F) between thoron and its progeny was determined in order to show the importance of direct progeny measurements for correct estimation of effective dose due to radon, thoron and their progenies. A total of 220 RADUET detectors were used to measure indoor radon and thoron and 130 TnP monitors for thoron progeny indoors. The arithmetic and geometric mean concentrations of Rn, Tn, and TnP were 103 and 89 Bq m, 173, and 118 Bq m, 10.7, and 7.4 Bq m, respectively. Total effective dose determined from radon, thoron, and their progenies was estimated at 4.2 ± 0.5 mSv y. Thoron equilibrium factor varied according to seasons, the type of dwelling, building materials and localities. Thoron (Tn and TnP) contribution to effective dose ranged between 3 and 80% with the average value of 53%. Total effective dose estimated from the world average equilibrium factor of 0.02 given by UNSCEAR was 2.7 ± 0.2 mSv y. The effective dose due to thoron varied greatly according to the different values taken by F and was different from that determined directly using TnP concentrations. Thus, effective dose due to thoron determined from the equilibrium factor is unreliable. Therefore, the risk of public exposure due to thoron (Tn and TnP) may therefore be higher than that of radon (Rn and RnP) in many parts of the world if F is no longer used in estimating total effective dose. This is not in contradiction with the UNSCEAR conclusions. It is therefore important to directly measure the radon and thoron progeny for a correct estimate of effective dose.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026246PMC
http://dx.doi.org/10.3389/fpubh.2020.00017DOI Listing

Publication Analysis

Top Keywords

effective dose
36
radon thoron
24
thoron progeny
16
equilibrium factor
16
thoron
14
total effective
12
effective
9
dose
9
direct progeny
8
progeny measurements
8

Similar Publications

Idiopathic Pulmonary Fibrosis (IPF) is a chronic respiratory disorder for which pirfenidone is the recommended first-line anti-fibrotic treatment. While pirfenidone has demonstrated efficacy in slowing the progression of IPF, its use is associated with several challenges and unresolved issues that impact patient outcomes. Pirfenidone administration can result in gastrointestinal side effects, photosensitivity reactions, and significant drug interactions, particularly in patients with hepatic impairment.

View Article and Find Full Text PDF

Background: Lamotrigine clearance can change drastically in pregnant women with epilepsy (PWWE) making it difficult to assess the need for dosing adjustments. Our objective was to characterize lamotrigine pharmacokinetics in PWWE during pregnancy and postpartum along with a control group of nonpregnant women with epilepsy (NPWWE).

Methods: The Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) study was a prospective, observational, 20 site, cohort study conducted in the United States (December 2012 and February 2016).

View Article and Find Full Text PDF

α-Cyclodextrin (αCD), a cyclic hexasaccharide composed of six glucose units, is not digested in the small intestine but is completely fermented by gut microbes. Recently, we have reported that αCD supplementation for nonathlete men improved their 10 km biking times. However, the beneficial effects of αCD on exercise are not yet fully understood.

View Article and Find Full Text PDF

Platelets as crucial players in the dynamic interplay of inflammation, immunity, and cancer: unveiling new strategies for cancer prevention.

Front Pharmacol

December 2024

Systems Pharmacology and Translational Therapeutics Laboratory, The Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University, Chieti, Italy.

Inflammation plays a critical role in the pathogenesis of various diseases by promoting the acquisition of new functional traits by different cell types. Shared risk factors between cardiovascular disease and cancer, including smoking, obesity, diabetes, high-fat diet, low physical activity, and alcohol consumption, contribute to inflammation linked to platelet activation. Platelets contribute to an inflammatory state by activating various normal cells, such as fibroblasts, immune cells, and vascular cells.

View Article and Find Full Text PDF

Overcoming (X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations.

Front Microbiol

December 2024

Guangdong Laboratory for Lingnan Modern Agriculture, National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

Introduction: The emergence of the wide variety of novel tigecycline resistance (X) variants, including (X3), (X4), (X5), and (X6), has raised a serious threat to global public health and posed a significant challenge to the clinical treatment of multidrug-resistant bacterial infections.

Methods: In this study, we evaluated the synergism of tigecycline combining with other antibiotics as a means of overcoming the (X)-mediated resistance in spp. Antibiotic synergistic efficacy was evaluated through chequerboard experiments, time-kill assays and dose-response curves.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!