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Analysis of the Clinicopathologic Characteristics of Lung Adenocarcinoma With Mutation. | LitMetric

Analysis of the Clinicopathologic Characteristics of Lung Adenocarcinoma With Mutation.

Front Genet

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Published: February 2020

AI Article Synopsis

Article Abstract

Introduction: Lung adenocarcinoma with mutation is relatively uncommon, and its clinicopathologic characteristics, disease course, and prognosis have not been well-studied.

Methods: A total of 564 lung adenocarcinoma patients were enrolled in this study. The relationship between mutational status and clinicopathologic parameters, the rates of relapse-free survival (RFS) and overall survival (OS), and the mutational status of other genes commonly mutated in lung adenocarcinoma were analyzed.

Results: Of 564 lung adenocarcinoma patients, 30 (5.3%) harbored mutations. Univariate analyses revealed that gender, smoking history, pleural invasion, and histological subtype were all significant predictors of RFS and OS. Pleural invasion and histological subtype remained significant predictors of RFS and OS in a multivariate analysis. There were no significant differences in RFS ( = 0.504) or OS ( = 0.054) between lung adenocarcinoma patients with mutation and those without mutation. However, patients with mutation tended to have a worse OS.

Conclusions: Female patients and nonsmokers are likely to harbor mutation and primary lung adenocarcinoma with mutated has a poor prognosis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026668PMC
http://dx.doi.org/10.3389/fgene.2019.01367DOI Listing

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