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Children's Cancer and Leukaemia Group (CCLG): review and guidelines for the management of meningioma in children, teenagers and young adults. | LitMetric

AI Article Synopsis

  • Primary tumours of the meninges are quite rare in children, making up only 0.4-4.6% of all pediatric central nervous system tumors, leading to a lack of clear treatment guidelines specifically for this population.
  • Existing treatment recommendations for pediatric meningiomas are largely based on studies from adults, which can complicate appropriate management in children.
  • Updated guidelines from 2019 built upon CCLG's 2009 recommendations, emphasizing the importance of complete surgical removal as the main treatment and discussing advancements in understanding genetic factors that could improve therapy and follow-up care for young survivors.

Article Abstract

Primary tumours of the meninges are rare accounting for only 0.4-4.6% of all paediatric tumours of the central nervous system. Due to the rarity of these tumours in children, and the consequent absence of collaborative prospective trials, there is no clear consensus on how the unique characteristics of paediatric meningiomas impact clinical status, management approach, and survival. Much of the evidence and treatment recommendations for paediatric meningiomas are extrapolated from adult data. Translating and adapting adult treatment recommendations into paediatric practice can be challenging and might inadvertently lead to inappropriate management. In 2009, Traunecker published guidelines for the management of intracranial meningioma in children and young people on behalf of UK Children's Cancer and Leukaemia Group (CCLG). Ten years later we have developed the updated guidelines following a comprehensive appraisal of the literature. Complete surgical resection is the treatment of choice for symptomatic meningiomas, while radiotherapy remains the only available adjuvant therapy and may be necessary for those tumours that cannot be completely removed. However, significant advances have been made in the identification of the genetic and molecular alterations of meningioma, which has not only a potential value in the development of therapeutic agents but also in surveillance of childhood meningioma survivors. This guideline builds upon the CCLG 2009 guideline. We summarise recommendations for the diagnosis, treatment, surveillance and long-term follow-up of children and adolescents with meningioma.

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Source
http://dx.doi.org/10.1080/02688697.2020.1726286DOI Listing

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