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http://dx.doi.org/10.1016/j.ram.2020.02.001 | DOI Listing |
Discov Oncol
January 2025
Department of Thoracic Surgery, Shanghai Public Health Clinical Center, Fudan University Shanghai, Caolang Highway 2901#, Jinshan District, Shanghai, People's Republic of China.
Background: Lung adenocarcinoma (LUAD) is a leading form of non-small cell lung cancer characterized by a complex tumor microenvironment (TME) that influences disease progression and therapeutic response. Tumor-associated macrophages (TAMs) within the TME promote tumorigenesis and evasion of immune surveillance, though their heterogeneity poses challenges in understanding their roles and therapeutic targeting. Additionally, traditional Chinese medicine (TCM) offers potential anti-cancer agents that could modulate the immune landscape.
View Article and Find Full Text PDFPLoS One
January 2025
Faculty of Sciences and Technology (FAST), Laboratory of Biology and Molecular Typing in Microbiology (LBTMM), University of Abomey-Calavi, Atlantic, Benin.
Background: Antiretroviral treatment increases the risk of accumulation of resistance mutations that negatively impact the possibilities of future treatment. This study aimed to present the frequency of HIV-1 antiretroviral resistance mutations and the genetic diversity among children with virological failure in five pediatric care facilities in Benin.
Methods: A cross-sectional study was carried out from November 20, 2020, to November 30, 2022, in children under 15 years of age who failed ongoing antiretroviral treatment at five facilities care in Benin (VL > 3log10 on two consecutive realizations three months apart).
Trop Biomed
December 2024
Resource Biotechnology Programme, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300, Kota Samarahan, Sarawak, Malaysia.
Leptospirosis is a severe and potentially fatal re-emerging zoonotic and waterborne disease caused by pathogenic and intermediate species of Leptospira. Given the high global rates of morbidity and mortality associated with this disease, there is an urgent need to explore alternative therapeutic agents to enhance treatment options. This study investigates the anti-leptospiral efficacy of several common antibiotics-penicillin G, doxycycline, ampicillin, amoxicillin, cefotaxime, chloramphenicol, and erythromycin, as well as extracts from local herbs, Hydnophytum formicarum Jack and Boesenbergia stenophylla, against pathogenic and intermediate Leptospira strains.
View Article and Find Full Text PDFCell Mol Gastroenterol Hepatol
January 2025
Ruy V. Lourenço Center for Emerging and Re-Emerging Pathogens, Rutgers New Jersey Medical School, Newark, New Jersey; Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:
Environ Sci Pollut Res Int
January 2025
Université Paris-Saclay, INRAE, AgroParisTech, UMR ECOSYS, 91120, Palaiseau, France.
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