AI Article Synopsis
- The adaptive immune response in jawed vertebrates is characterized by diverse antigen receptors (B cell and T cell), which make it challenging to analyze without high-throughput sequencing (HTS) technologies.
- HTS has transformed how scientists study the immune system, enabling deeper insights into the behavior and clonal dynamics of antigen-specific B and T cells.
- This review discusses both traditional and modern methods for analyzing immunoglobulin and T cell receptor diversity, highlighting their relevance in basic and clinical immunology.
Article Abstract
The adaptive immune response in jawed vertebrates relies on the huge diversity and specificity of the B cell and T cell antigen receptors, the immunoglobulins (IG) or antibodies and the T cell receptors (TR), respectively. The high level of diversity has represented a barrier to a comprehensive analysis of the adaptive immune response before the emergence of high-throughput sequencing (HTS) technologies. The size and complexity of HTS data requires the generation of novel computational and analytical approaches, which are transforming how the adaptive immune responses are deciphered to understand the clonal dynamics and properties of antigen-specific B and T cells in response to different kind of antigens. This exciting and rapidly evolving field is not only impacting human and clinical immunology but also comparative immunology. We are now closer to understanding the evolution of adaptive immune response in jawed vertebrates. This review provides an overview about classical and current strategies developed to assess the IG/TR diversity and their applications in basic and clinical immunology.
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| http://dx.doi.org/10.1016/j.imlet.2020.02.013 | DOI Listing |
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