Automated three-step two-pot production of no-carrier-added (NCA) [F]FDOPA was first implemented in the iPHASE FlexLab module. Decay-corrected radiochemical yield (RCY) of [F]FDOPA synthesized by this method was 10~14% (n = 7) with a synthesis time of ~110 min [F]FDOPA was obtained in > 95% of radiochemical purity with a molar activity of ~431 GBq/μmol. With the method successfully implementing on the commercial FlexLab module and its built-in step-by-step activity monitoring, further processes optimization would be achieved.
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| http://dx.doi.org/10.1016/j.apradiso.2019.108871 | DOI Listing |
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