AI Article Synopsis
- Cytomegalovirus (CMV) infection significantly impacts the health outcomes of kidney transplant (KT) recipients, especially in the first year post-transplant.
- A study analyzing KT recipients in Thailand found that CMV serostatus (both donor and recipient) serves as a predictor for mortality, with those mismatched for CMV being at a higher risk.
- Overall, while the allograft loss rate was relatively low (3.8%), the mortality rate within the first year was notable at 2.8%, highlighting the need for careful monitoring of CMV serostatus in KT patients to improve survival outcomes.
Article Abstract
Background: Cytomegalovirus (CMV) infection is one of the leading causes of morbidity and mortality in kidney transplantation (KT) recipients. We investigated the association of CMV serostatus and patient outcomes within the first year after KT.
Methods: All KT recipients between January 1, 2007 and December 31, 2017 were identified from the Thai Transplant Registry. The prevalence rates of allograft loss and mortality within the first year after KT were estimated by the Kaplan-Meier method. The CMV serostatus in donors (D) and recipients (R) was assessed as a prognostic factor for allograft loss and mortality within the first year by the Cox proportional hazards model.
Results: During the 10-year study period (2007-2017), there were 4556 KT recipients with a mean ± standard deviation age of 43 ± 14 years, and 63% of the recipients were male. Deceased-donor KT and induction therapy were performed in 52% and 58% of the recipients, respectively. Among the 3907 evaluable patients, the rates of cases with D/R, D/R, D/R, and D/R as the CMV serostatus were 88.9%, 6.1%, 2.9%, and 1.9%, respectively. The estimated prevalence rates of allograft loss and mortality within the first year were 3.8% and 2.8%, respectively. In univariate analysis, CMV D/R serostatus was significantly associated with mortality (hazard ratio [HR], 2.10; 95% confidence interval [CI], 1.18-3.75; P = .01) but not with an allograft loss (HR, 1.51; 95% CI, 0.85-2.66; P = .16) within the first year after KT. In multivariate analysis, CMV D/R serostatus of D/R was associated with mortality within the first year after KT (HR, 2.04; 95% CI, 1.05-3.95; P = .04). Other independent prognostic factors for mortality were old recipient age, deceased-donor KT, and hemodialysis after KT.
Conclusions: In a national setting with predominant CMV seropositivity in both D and R, CMV seromismatch was associated with poor patient survival within the first year after KT.
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| http://dx.doi.org/10.1016/j.transproceed.2020.01.028 | DOI Listing |
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