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The mitochondrial function of peripheral blood mononuclear cells in frail older patients.
Exp Gerontol
November 2024
Division of Geriatric Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, China. Electronic address:
Article Synopsis
- Frailty is linked to increased health risks in older adults, but diagnosing it is complicated due to varied symptoms and underlying causes, prompting a study to explore mitochondrial function as a potential biomarker for frailty.* -
- In a study of 393 participants aged 25-100, researchers assessed frailty using the physical frailty phenotype scale and analyzed various mitochondrial functions and morphology in peripheral blood mononuclear cells (PBMCs).* -
- Results showed significant differences in mitochondrial characteristics and functions between frail and non-frail older adults, highlighting potential correlations between mitochondrial health and frailty status, particularly regarding factors like mtDNA copy number and respiratory function.*
Structural basis for regulated assembly of the mitochondrial fission GTPase Drp1.
Nat Commun
February 2024
Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Mitochondrial fission is a critical cellular event to maintain organelle function. This multistep process is initiated by the enhanced recruitment and oligomerization of dynamin-related protein 1 (Drp1) at the surface of mitochondria. As such, Drp1 is essential for inducing mitochondrial division in mammalian cells, and homologous proteins are found in all eukaryotes.
View Article and Find Full Text PDFLate pregnancy maternal naringin supplementation affects the mitochondria in the cerebellum of Wistar rat offspring via sirtuin 3 and AKT.
Int J Dev Neurosci
April 2024
Programa de Pós-Graduação em Ciências Biológicas - Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Dietary polyphenol consumption is associated with a wide range of neuroprotective effects by improving mitochondrial function and signaling. Consequently, the use of polyphenol supplementation has been investigated as an approach to prevent neurodevelopmental diseases during gestation; however, the data obtained are still very inconclusive, mostly because of the difficulty of choosing the correct doses and period of administration to properly prevent neurodegenerative diseases without undermining normal brain development. Thus, we aimed to evaluate the effect of naringin supplementation during the third week of gestation on mitochondrial health and signaling in the cerebellum of 21-day-old offspring.
View Article and Find Full Text PDFCorrection: Ablation of dynamin-related protein 1 promotes diabetes-induced synaptic injury in the hippocampus.
Cell Death Dis
June 2021
Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju, Gyeongnam, 52727, Republic of Korea.
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