AI Article Synopsis
- The study aimed to assess whether measuring cerebrospinal fluid (CSF) ferritin levels can help diagnose purulent meningitis (PM) in children.
- Researchers analyzed 81 children suspected of having meningitis, measuring CSF ferritin levels and comparing results across three diagnostic groups: PM, aseptic meningitis (AM), and no meningitis.
- Findings showed significantly higher CSF ferritin levels in children with PM compared to those with AM or no meningitis, suggesting that CSF ferritin could serve as a valuable biomarker for diagnosing PM in affected children.
Article Abstract
Objective: To evaluate the use of cerebrospinal fluid (CSF) ferritin levels in the diagnosis of purulent meningitis (PM).
Method: We studied 81 children between 28 days and 12 years of age who presented with clinical suspicion of meningitis to the emergency department. CSF ferritin levels were measured and compared between diagnostic groups (PM, aseptic meningitis (AM) and no meningitis).
Results: The median age was 24 (IQR 8-69) months. There were 32 patients with AM (39%), 23 with PM (28%) and 26 with no meningitis (32%). Median CSF ferritin was 4.2 ng/mL (IQR 3.0-6.5), 52.9 ng/mL (IQR 30.7-103 ng/mL) and 2.4 ng/mL (IQR 2-4), respectively. CSF ferritin was higher in children with PM compared with AM (p<0.001) or no meningitis (p<0.001). There was no difference between AM and no meningitis.
Conclusion: CSF ferritin may be a useful biomarker to discriminate PM in children with clinical symptoms of this disease.
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| http://dx.doi.org/10.1136/archdischild-2019-317960 | DOI Listing |
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Article Synopsis
- The study systematically reviewed biomarkers in cerebrospinal fluid (CSF) and blood for diagnosing paediatric bacterial meningitis.
- It included 112 articles on 113 individual biomarkers, finding significant differences in concentrations between bacterial and viral meningitis.
- Key CSF biomarkers like CRP, IL-6, and procalcitonin showed excellent accuracy in distinguishing bacterial meningitis from other infections, supporting their potential use in clinical settings.
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