The first-order Fermi acceleration of electrons requires an injection of electrons into a mildly relativistic energy range. However, the mechanism of injection has remained a puzzle both in theory and observation. We present direct evidence for a novel stochastic shock drift acceleration theory for the injection obtained with Magnetospheric Multiscale observations at the Earth's bow shock. The theoretical model can explain electron acceleration to mildly relativistic energies at high-speed astrophysical shocks, which may provide a solution to the long-standing issue of electron injection.
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http://dx.doi.org/10.1103/PhysRevLett.124.065101 | DOI Listing |
Cell Stress Chaperones
December 2024
CONAHCYT, Centro de Investigaciones Biológicas del Noroeste, La Paz, Mexico. Electronic address:
Understanding the molecular mechanisms underlying thermal acclimation and heat shock responses in marine ectotherms is critical for assessing their adaptive capacity in the context of climate change and climate extremes. This study examines the expression dynamics of heat shock proteins (HSPs) in the scallop Nodipecten subnodosus, shedding light on their role in thermal adaptation. Our analysis revealed the presence of several conserved functional signatures in N.
View Article and Find Full Text PDFTher Drug Monit
December 2024
Department of Pharmaceutical and Pharmacological Sciences, KU Leuven.
Background: In adult patients with sepsis or septic shock admitted to the emergency department, a single intravenous 15 mg/kg amikacin dose provides inadequate pharmacokinetic-pharmacodynamic target attainment at the locally reported minimum inhibitory concentration (MIC) of 2 mg/L and the European Committee on Antimicrobial Susceptibility Testing clinical breakpoint for Enterobacterales of 8 mg/L.
Objectives: To provide an amikacin dosing strategy with a clinically acceptable probability of target attainment (PTA) for all patients.
Methods: Stochastic simulations were performed using a two-compartment population pharmacokinetics model of amikacin (NONMEM 7.
Front Microbiol
November 2024
Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, United States.
Introduction: The molecular mechanisms underlying pressure adaptation remain largely unexplored, despite their significance for understanding biological adaptation and improving sterilization methods in the food and beverage industry. The heat shock response leads to a global stabilization of the proteome. Prior research suggested that the heat shock regulon may exhibit a transcriptional response to high-pressure stress.
View Article and Find Full Text PDFJ Math Biol
November 2024
Integrated Risk Management Division, Tokyo Star Bank, Ltd., Akasaka 2-3-5, Minato-ku, Tokyo, 107-8480, Japan.
The purpose of this study is to construct a mortality model that reasonably explains survival curves and mortality rates in terms of the decline in biological function, which is the phenomenon of ageing. In this model, an individual organism is regarded as a collection of subsystems, and for each subsystem, the model defines human mortality by introducing positive self-repair mechanisms and stochastically generated negative external shocks. The probability density function of the time of death is derived explicitly, and the model parameters are estimated using life tables from Japan and the UK, which demonstrate the existence of multiple parameter sets that fit well with the observed data.
View Article and Find Full Text PDFSci Adv
November 2024
Universität Hamburg, Hamburger Sternwarte, Gojenbergsweg 112, 21029 Hamburg, Germany.
Supersonic turbulence occurs in many environments, particularly in astrophysics. In the crucial case of isothermal turbulence, the probability density function (PDF) of the logarithmic density, , is well measured, but a theoretical understanding of the processes leading to this distribution remains elusive. We investigate these processes using Lagrangian tracer particles to track and [Formula: see text] in direct numerical simulations, and we show that their evolution can be modeled as a stochastic differential process with time-correlated noise.
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