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Antimicrobial host defence peptides: functions and clinical potential. | LitMetric

Antimicrobial host defence peptides: functions and clinical potential.

Nat Rev Drug Discov

University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.

Published: May 2020

AI Article Synopsis

Article Abstract

Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally occurring peptides that can combat infections through their direct microbicidal properties and/or by influencing the host's immune responses. The unique ability of CHDP to control infections as well as resolve harmful inflammation has generated interest in harnessing the properties of these peptides to develop new therapies for infectious diseases, chronic inflammatory disorders and wound healing. Various strategies have been used to design synthetic optimized peptides, with negligible toxicity. Here, we focus on the progress made in understanding the scope of functions of CHDP and the emerging potential clinical applications of CHDP-based therapies.

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41573-019-0058-8DOI Listing

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