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Immune Biomarkers on Tissue Microarray Cores Support the Presence of Adjacent Tertiary Lymphoid Structures in Soft Tissue Sarcoma.
Lab Invest
January 2025
Interdisciplinary Oncology, University of British Columbia, Vancouver, Canada; Molecular and Advanced Pathology Core, University of British Columbia, Vancouver, Canada; Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada. Electronic address:
Immunotherapy has emerged as a new treatment modality in some soft tissue sarcomas, particularly for tumors associated with tertiary lymphoid structures (TLS). These structures are functional lymphoid aggregates, and their presence is indicative of an active anticancer immune response in the tumor microenvironment. The assessment of TLS as a predictive biomarker at scale on patient specimens remains challenging.
View Article and Find Full Text PDFUnusual Presentation of Large Retroperitoneal Lipoma in a 3-Year-Old Child: A Case Report.
Clin Med Insights Case Rep
January 2025
Department of Radiology, Haramaya University College of Health and Medical Sciences, Harar, Ethiopia.
Background: Lipomas can occur almost anywhere in the body, but they are exceptionally rare in the retroperitoneal region. While lipomas are common in adults, they are quite uncommon in children. Even among adults, retroperitoneal lipomas are not frequently encountered.
View Article and Find Full Text PDFThoracoscopic resection of primary mediastinal liposarcoma: a case report and literature review.
J Cardiothorac Surg
January 2025
Department of Cardiothoracic Surgery, The First People's Hospital of Neijiang, No. 1866, West Section of Hanan Avenue, Shizhong District, Neijiang, Sichuan, 641000, P.R. China.
Background: Primary mediastinal liposarcomas (PLMs) are extremely rare. Patients typically present with symptoms caused by tumor size, as the mass can compress surrounding tissues and organs. Here, we report a case of a large primary mediastinal liposarcoma that was successfully resected thoracoscopically.
View Article and Find Full Text PDFImaging of unicentric hyaline-vascular variant of Castleman disease: Emphasis on perilesional fat stranding and fatty proliferation.
Glob Health Med
December 2024
Department of Radiology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
The hyaline-vascular variant of Castleman disease (HVCD) is relatively uncommon and demonstrates no specific clinical or laboratory findings; therefore, its preoperative diagnosis warrants a radiological evaluation. This study aimed to review imaging findings of HVCD, focusing on perilesional fat stranding and fatty proliferation. Patients with a pathologically confirmed HVCD diagnosis who had undergone CT were recruited from five hospitals from January 2000 to March 2023.
View Article and Find Full Text PDFRetroperitoneal leiomyosarcoma diagnosis and management in a chronic kidney disease context: A case report.
Int J Surg Case Rep
January 2025
Department of Surgery A La Rabta Hospital, Tunis, Tunisia; Faculty of medicine of Tunis, Tunis El Manar University, Tunis, Tunisia.
Introduction And Importance: While the treatment approach for sarcomas seems straightforward and well-defined, we often encounter several diagnostic or therapeutic challenges in clinical practice. This article presents a case of retroperitoneal leiomyosarcoma in a patient with chronic kidney disease, highlighting the complexity of managing such cases.
Case Report: A 63-year-old woman with a history of chronic kidney disease presented with a progressively enlarging mass in her right flank.
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