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RNA at DNA Double-Strand Breaks: The Challenge of Dealing with DNA:RNA Hybrids. | LitMetric

RNA at DNA Double-Strand Breaks: The Challenge of Dealing with DNA:RNA Hybrids.

Bioessays

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91, Stockholm, Sweden.

Published: May 2020

AI Article Synopsis

  • * DilncRNAs can be processed into shorter molecules or form hybrids with DNA, playing a crucial role in the recruitment of repair factors for accurate DNA repair through homologous recombination.
  • * If DNA:RNA hybrids are not properly managed, they can become mutagenic and hinder DNA repair processes, which has sparked discussions on managing dilncRNAs and their effects on DNA repair.

Article Abstract

RNA polymerase II is recruited to DNA double-strand breaks (DSBs), transcribes the sequences that flank the break and produces a novel RNA type that has been termed damage-induced long non-coding RNA (dilncRNA). DilncRNAs can be processed into short, miRNA-like molecules or degraded by different ribonucleases. They can also form double-stranded RNAs or DNA:RNA hybrids. The DNA:RNA hybrids formed at DSBs contribute to the recruitment of repair factors during the early steps of homologous recombination (HR) and, in this way, contribute to the accuracy of the DNA repair. However, if not resolved, the DNA:RNA hybrids are highly mutagenic and prevent the recruitment of later HR factors. Here recent discoveries about the synthesis, processing, and degradation of dilncRNAs are revised. The focus is on RNA clearance, a necessary step for the successful repair of DSBs and the aim is to reconcile contradictory findings on the effects of dilncRNAs and DNA:RNA hybrids in HR.

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Source
http://dx.doi.org/10.1002/bies.201900225DOI Listing

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