AI Article Synopsis
- A new method for alkylating o-disubstituted aryl ketones using racemic secondary alcohols has been developed, which enhances enantioselectivity.
- The process utilizes a commercially available iridium catalyst and operates through a mechanism called hydrogen borrowing catalysis.
- The resulting β-substituted ketones can be easily modified into various functional groups through a reaction called retro-Friedel-Crafts acylation.
Article Abstract
An enantioconvergent method for the alkylation of o-disubstituted aryl ketones with racemic secondary alcohols is described. This process is mediated by a commercially available iridium catalyst and proceeds via hydrogen borrowing catalysis. The highly enantioenriched β-substituted ketone products were readily cleaved to a wide range of functional groups via retro-Friedel-Crafts acylation.
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| http://dx.doi.org/10.1039/d0cc00767f | DOI Listing |
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