AI Article Synopsis
- Esophageal carcinoma is a serious cancer with poor outcomes, and the study investigates the role of a newly discovered microRNA, miR-1304, in patients with this condition.
- Researchers analyzed the expression of miR-1304 using data from The Cancer Genome Atlas and tested its levels in patient tissues and blood.
- The findings show that higher levels of miR-1304 correlate with larger tumor sizes, poorer differentiation, and worse survival rates, indicating its potential as a diagnostic and prognostic marker for esophageal carcinoma.*
Article Abstract
Background: Esophageal carcinoma is a malignant gastrointestinal tumor with a very poor prognosis. MicroRNA (miR)-1304 is a newly discovered non-coding RNA, which shows differential expression in other cancers, and its clinical value in esophageal carcinoma remains unclear.
Aim: To explore the expression of miR-1304 in patients with esophageal carcinoma and its clinical value.
Methods: The expression of miR-1304 in patients with esophageal carcinoma was analyzed based on the data on miR in esophageal carcinoma downloaded from The Cancer Genome Atlas database. Quantitative real-time polymerase chain reaction was adopted to determine the expression of miR-1304 in the tissues and serum of patients. The clinical diagnostic value of miR-1304 and independent factors for recurrence and prognosis of esophageal carcinoma were then analyzed. The potential target genes of miR-1304 were predicted, and then analyzed based on gene ontology, Kyoto Encyclopedia of Genes, and Genomes, and protein-protein interaction.
Results: The expression of miR-1304 in the tissues and serum of patients with esophageal carcinoma increased, and was also increased according to the database. Patients with high expression of miR-1304 suffered increased rates of tumor ≥ 3 cm, low differentiation and stage II + III. miR-1304 had a diagnostic value in identifying esophageal carcinoma, tumor size, differentiation and TNM stage. Tumor size, differentiation, TNM stage, and miR-1304 were independent risk factors for recurrence of esophageal carcinoma, and they had certain predictive and diagnostic value for the recurrence of esophageal carcinoma. Seventy-eight patients showed a 3-year survival rate of 38.46%, and patients with high expression of miR-1304 had a relatively lower survival rate. Multivariate analysis revealed that tumor size, differentiation, recurrence and miR-1304 were independent factors for the prognosis of patients. MiRTarBase, miRDB, and Targetscan predicted 20 target genes in total. Gene ontology enrichment analysis found 18 functions with < 0.05, and Kyoto Encyclopedia of Genes, and Genomes analysis found 11 signal pathways with < 0.05. String analysis of protein co-expression found 269 relationship pairs, of which co-expression with epidermal growth factor was the most common.
Conclusion: miR-1304 can be used as a potential indicator for the diagnosis and recurrence of esophageal carcinoma and for survival of patients with this disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029348 | PMC |
| http://dx.doi.org/10.3748/wjg.v26.i6.670 | DOI Listing |
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