AI Article Synopsis
- Peripheral neuropathy (PN) affects about 5% of people over 50, with various causes such as genetics, diabetes, alcohol, and vitamin deficiencies.
- A systematic review analyzed 69 studies to explore the link between oxidative stress and PN, finding that reactive oxygen species increase while antioxidants decrease in those with the condition.
- The review suggests that oxidative stress plays a role in PN’s development, and while antioxidant treatments show promise, more research is needed to fully understand the mechanisms involved.
Article Abstract
Peripheral neuropathy (PN) is a common disease affecting about 5% of the general population after the age of 50. Causes of PN are numerous and include genetic, diabetes, alcohol, vitamin deficiencies, and gluten sensitivity among others. This systematic review aimed to study the association between oxidative stress and PN in an attempt to better understand PN pathogenesis. A computer-based, systematic search was conducted on the PubMed database, and ensuing data from included articles was analyzed and discussed in this review. Sixty-nine papers were eligible and were used for this review. Peripheral neuropathy is associated with an increase of reactive oxygen species and a decrease in endogenous antioxidants. Genetic predisposition to oxidative damage may be a factor. Antioxidant treatment is promising regarding treatment. Though further research is necessary to better understand the underlying mechanism, it is evident that oxidative stress is implicated in the pathogenesis of - or is at least systematically present in - PN.
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| http://dx.doi.org/10.1007/s12031-020-01495-x | DOI Listing |
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