MitoBlue is a fluorescent bisamidine that can be used to easily monitor the changes in mitochondrial degradation processes in different cells and cellular conditions. MitoBlue staining pattern is exceptional among mitochondrial dyes and recombinant fluorescent probes, allowing the dynamic study of mitochondrial recycling in a variety of situations in living cells. MitoBlue is a unique tool for the study of these processes that will allow the detailed characterization of communication between mitochondria and lysosomes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044336 | PMC |
| http://dx.doi.org/10.1038/s41598-020-60573-7 | DOI Listing |
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MitoBlue as a tool to analyze the mitochondria-lysosome communication.
Sci Rep
February 2020
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Bioquímica y Biología Molecular, Universidade de Santiago de Compostela, 15782, Santiago de, Compostela, Spain.
MitoBlue is a fluorescent bisamidine that can be used to easily monitor the changes in mitochondrial degradation processes in different cells and cellular conditions. MitoBlue staining pattern is exceptional among mitochondrial dyes and recombinant fluorescent probes, allowing the dynamic study of mitochondrial recycling in a variety of situations in living cells. MitoBlue is a unique tool for the study of these processes that will allow the detailed characterization of communication between mitochondria and lysosomes.
View Article and Find Full Text PDFMitoBlue: a nontoxic and photostable blue-emitting dye that selectively labels functional mitochondria.
ACS Chem Biol
December 2014
Departamento de Química Orgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), and ‡Departamento de Bioquímica y Biología Molecular and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
Article Synopsis
- A new fluorogenic dye called MitoBlue has been discovered that specifically stains active mitochondria while being low in toxicity and resistant to photobleaching.
- MitoBlue emits a bright blue color, making it useful for visualizing mitochondria in biological samples.
- A modified version of MitoBlue with a biotin label can help deliver streptavidin-tagged substances directly to the mitochondria.
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