Objective: Epicardial adipose tissue (EAT) is an active endocrine organ that could contribute to the pathophysiology of coronary artery disease (CAD) through the paracrine release of proatherogenic mediators. Numerous works have analyzed the inflammatory signature of EAT, but scarce informations on its lipidome are available. Our objective was first to study the differences between EAT and subcutaneous adipose tissue (SAT) lipidomes and second to identify the specific untargeted lipidomic signatures of EAT and SAT in CAD. Approach and Results: Subcutaneous and EAT untargeted lipidomic analysis was performed in 25 patients with CAD and 14 patients without CAD and compared with paired plasma lipidomic analysis of isolated VLDL (very low-density lipoprotein) and HDL (high-density lipoprotein). Lipidomics was performed on a C18 column hyphenated to a Q-Exactive plus mass spectrometer, using both positive and negative ionization mode. EAT and SAT had independent lipidomic profile, with 95 lipid species differentially expressed and phosphatidylethanolamine 18:1p/22:6 twenty-fold more expressed in EAT compared with SAT false discovery rate =3×10). Patients with CAD exhibited more ceramides (=0.01), diglycerides (=0.004; saturated and nonsaturated), monoglycerides (=0.013) in their EAT than patients without CAD. Conversely, they had lesser unsaturated TG (triglycerides; =0.02). No difference was observed in the 295 lipid species found in SAT between patients with and without CAD. Fifty-one lipid species were found in common between EAT and plasma lipoproteins. TG 18:0/18:0/18:1 was found positively correlated (=0.45, =0.019) in EAT and HDL and in EAT and VLDL (=0.46, =0.02).
Conclusions: CAD is associated with specific lipidomic signature of EAT, unlike SAT. Plasma lipoprotein lipidome only partially reflected EAT lipidome.
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http://dx.doi.org/10.1161/ATVBAHA.120.313955 | DOI Listing |
Int J Cardiol Congenit Heart Dis
June 2023
Adult Congenital Heart Disease Unit, Department of Cardiology, Monaldi Hospital, Naples, Italy.
Thanks to advances in both medical care and surgical techniques, over recent years, survival for patients with congenital heart disease (CHD) has increased significantly, with about 90% of patients now reaching adulthood. However, as CHD patients grow older, their relative risk of developing coronary artery disease (CAD) increases. Moreover, it has been demonstrated that the majority of adult congenital heart disease (ACHD) patients has at least one cardiovascular risk factor.
View Article and Find Full Text PDFAerosp Med Hum Perform
December 2024
Introduction: Left bundle branch block (LBBB) is disqualifying for aircrew in the U.S. Air Force (USAF), although outcomes for these patients is limited.
View Article and Find Full Text PDFJ Esthet Restor Dent
December 2024
Department of Fixed Prosthodontics, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
Objective: To assess the effect of chairside adjustment and polishing on the clinical performance of zirconia endocrowns and digitally calculate the opposing enamel wear.
Materials And Methods: A total of 20 participants received zirconia endocrowns on their endodontically treated lower first molars. All endocrowns were fabricated using CAD/CAM technology.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
December 2024
Selcuk University Medical Faculty, Department of Nuclear Medicine, Konya, Turkey.
Introduction And Objectives: Tissue attenuation reduces the specificity of the myocardial perfusion imaging single photon emission tomography (SPECT), which leads reduced diagnostic accuracy. The aim of this study is to compare performances of non-attenuation corrected (NAC), computed tomography based-attenuation corrected (AC) and prone images for qualitative and semi-quantitative analysis of myocardial perfusion SPECT in diagnosis of coronary artery disease (CAD).
Materials And Methods: Eightysix patients in whom NAC, AC and prone images were obtained with SPECT at Selcuk University Faculty of Medicine, and whose coronary angiography/CT coronary angiography was completed within 3 months, were retrospectively studied.
Ann Noninvasive Electrocardiol
January 2025
University of Cologne, Faculty of Medicineand University Hospital Cologne, Cologne, Germany.
Background: Exercise electrocardiogram (ECG) is frequently used for evaluating patients with suspected coronary artery disease (CAD). However, it has been downgraded in international guidelines due to a limited sensitivity and specificity, compared with other non-invasive tests.
Methods: We hypothesized, that a sufficient exertion going beyond 85% of the age predicted maximal heart rate (APMHR), by considering the achieved level of workload can improve sensitivity and specificity of the exercise ECG.
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