This study investigates the effects of soft-robot geometry on magnetic guiding to develop an efficient helical mediator on a three-dimensional (3D) gastric cancer model. Four different magnetically active helical soft robots are synthesized by the inclusion of 5-μm iron particles in polydimethylsiloxane matrices. The soft robots are named based on the diameter and length (D2-L15, D5-L20, D5-L25, and D5-L35) with samples having varied helical pitch and weight values. Then, the four samples are tested on a flat surface as well as a stomach model with various 3D wrinkles. We analyze the underlying physics of intermittent magnetomotility for the helix on a flat surface. In addition, we extract representative failure cases of magnetomotility on the stomach model. The D5-L25 sample was the most suitable among the four samples for a helical soft robot that can be moved to a target lesion by the magnetic-flux density of the stomach model. The effects of diameter, length, pitch, and weight of a helical soft robot on magnetomotility are discussed in order for the robot to reach the target lesion successfully via magnetomotility.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078772 | PMC |
| http://dx.doi.org/10.3390/ma13041014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Spiral and helical formation of passive and active polymers with stiffness heterogeneity in a spherical cavity.
Soft Matter
January 2025
College of Chemistry, Sichuan University, Chengdu 610064, China.
Biomolecules usually adopt ubiquitous circular structures which are important for their functionality. Based on three-dimensional Langevin dynamics simulations, we investigate the conformational change of a polymer confined in a spherical cavity. Both passive and active polymers with either homogeneous or heterogeneous stiffness are analyzed in a comparative manner.
View Article and Find Full Text PDFStructural insights into glucose-6-phosphate recognition and hydrolysis by human G6PC1.
Proc Natl Acad Sci U S A
January 2025
Beijing National Laboratory for Condensed Matter Physics, Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
The glucose-6-phosphatase (G6Pase) is an integral membrane protein that catalyzes the hydrolysis of glucose-6-phosphate (G6P) in the endoplasmic reticulum lumen and plays a vital role in glucose homeostasis. Dysregulation or genetic mutations of G6Pase are associated with diabetes and glycogen storage disease 1a (GSD-1a). Studies have characterized the biophysical and biochemical properties of G6Pase; however, the structure and substrate recognition mechanism of G6Pase remain unclear.
View Article and Find Full Text PDFCharacterization of the polysaccharide schizophyllan and schizophyllan-chitosan hydrogel formation by diffusing-wave spectroscopy.
Carbohydr Polym
March 2025
Biophysics and Medical Technology, Department of Physics, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
Schizophyllan (SPG) is a semi-flexible, triple-helical polysaccharide with attractive properties as an efficient viscosifying compound and biological response modifier. We report microrheological characterization of schizophyllan as dispersed in solution and the changes associated when crosslinked with chitosan over an extended frequency range using diffusing wave spectroscopy (DWS). A SPG with high molecular weight (M = 1.
View Article and Find Full Text PDFα-Synuclein interaction with POPC/POPS vesicles.
Soft Matter
January 2025
Physical Chemistry, Chemistry Centre, Lund University, SE-22100 Lund, Sweden.
Article Synopsis
- The study explores how the amyloid-forming protein α-Synuclein (αSyn) attaches to lipid vesicles made from zwitterionic and anionic lipids, revealing that αSyn prefers to bind with the anionic components, adopting an α-helical structure.
- The extent of this adsorption is influenced by the proportion of anionic lipid present, affected by electrostatic interactions, particularly with serine residues.
- As fibrils form from αSyn due to the introduction of pre-formed fibril seeds, the vesicles experience significant size increase, attributed to the fusion of vesicles during this fibril formation process.
Deciphering Polymer Interactions in Bioconjugates with Different Architectures by Structural Analysis via Time-Resolved Limited Proteolysis Mass Spectrometry.
Angew Chem Int Ed Engl
January 2025
Universität Würzburg, Institute for Pharmacy and Food Chemistry, Am Hubland, 97074, Würzburg, Germany.
Therapeutic proteins are commonly conjugated with polymers to modulate their pharmacokinetics but often lack a description of the polymer-protein interaction. We deployed limited proteolysis mass spectrometry (LiP-MS) to reveal the interaction of polyethylene glycol (PEG) and PEG alternative polymers with interferon-α2a (IFN). Target conjugates were digested with the specific protease trypsin and a "heavy" N-IFN wild type (IFN-WT) for time-resolved quantification of the cleavage dynamics.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!