AI Article Synopsis
- Emerging research shows that glioma cells interact with the brain's environment in ways that can affect tumor growth.
- These interactions involve communication between glioma cells and other cell types, mainly through the transfer of genetic material using extracellular vesicles (EVs), which enhance neuronal activity.
- Blocking the release of EVs may reduce glioma growth, highlighting their role in modifying the tumor microenvironment and supporting tumor development.
Article Abstract
Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. Combining a genetic strategy with longitudinal live imaging, we find that individual gliomas communicate with distinct sets of non-glioma cells, including glial cells, neurons, and vascular cells. Transfer of genetic material is achieved mainly through extracellular vesicles (EVs), although cell fusion also plays a minor role. We further demonstrate that EV-mediated communication leads to the increase of synaptic activity in neurons. Blocking EV release causes a reduction of glioma growth in vivo. Our findings indicate that EV-mediated interaction between glioma cells and non-glioma brain cells alters the tumor microenvironment and contributes to glioma development.
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| http://dx.doi.org/10.1016/j.celrep.2020.01.089 | DOI Listing |
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