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Background: Hypersensitivity reactions to chemotherapy disrupt treatment schedules and compromise patient outcomes. Rapid Drug Desensitization (RDD) enables patients to tolerate future treatments after an allergy workup. However, Same-Day Desensitization (SDD) is a novel approach that capitalizes on RDD to allow the continuation of chemotherapy on the same day as the index reaction, preventing treatment delays.

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Background: Blood group incompatibility previously represented an obstacle to living related donor (LRD) options; desensitization modalities have expanded LRD options. ABO-incompatible kidney transplants have been successful in adults and pediatric liver transplants, but to date not yet in pediatric kidney transplants in South Africa.

Case Report: Patient X is a 5 year old male with end-stage kidney failure due to Posterior Urethral Valves, requiring peritoneal dialysis pre-transplant.

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Gelatin-Modified Bioactive Glass for Treatment of Dentin Hypersensitivity.

Int J Mol Sci

November 2024

School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.

Article Synopsis
  • Dentin hypersensitivity occurs when exposed dentin, often due to a lack of enamel, reacts to external stimuli, causing discomfort.
  • A new treatment using gelatin-modified bioactive glass (MBG@PDA@Gel) effectively blocks dentin tubules and promotes mineralization, showing better results than the traditional agent Gluma in lab tests.
  • Animal studies revealed that MBG@PDA@Gel not only remineralizes demineralized dentin effectively but also remains stable in the oral cavity, enhancing the biocompatibility of the material.
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Allergen-specific immunotherapy (AIT) induces immune tolerance, showing the highest success rate (>95%) for insect venom while a much lower chance for pollen allergy. However, the molecular switches leading to successful durable tolerance restoration remain elusive. The primary outcome of this observational study is the comprehensive immunological cellular characterization during the AIT initiation phase, whereas the secondary outcomes are the serological and Th2-cell-type-specific transcriptomic analyses.

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