AI Article Synopsis
- Diabetic cardiomyopathy (DCM) is a serious complication of type 2 diabetes mellitus (T2DM) that negatively affects heart function, and the study investigates how icariin (ICA), a flavonoid from the Epimedium plant, can improve this condition.
- The research involved creating a rat model of T2DM to observe the effects of ICA, noting that untreated rats exhibited significant heart issues and inflammation, while those treated with ICA showed notable improvements.
- Results indicated that ICA treatment reduced harmful extracellular matrix proteins in heart tissue, suggesting its potential as a therapeutic option for managing DCM in humans with T2DM.
Article Abstract
Objective: Diabetic cardiomyopathy (DCM) is a serious complication of type 2 diabetes mellitus (T2DM), resulting in unfavorable prognosis. Icariin (ICA) is a major flavonoid isolated from the traditional oriental herbal medicine Epimedium that has been recently proved to show potential therapeutic efficacy on T2DM. The aim of this study was to investigate the underlying mechanism of how ICA improved DCM in rat models.
Methods: To corroborate myocardial improvement by ICA, we managed to establish the T2DM rat model by streptozotocin (STZ) administration and high-glucose-high-fat diet.
Results: The rats with T2DM showed severe insulin resistance, left ventricular dysfunction, aberrant lipids deposition, cardiac inflammation, and fibrosis compared with the control group. All these pathological symptoms were ameliorated by the treatment of ICA. The levels of extracellular matrix proteins of heart tissue significantly declined in ICA-treated rats.
Conclusion: ICA may exert as a protector in T2DM-induced DCM by reducing extracellular matrix proteins in the heart tissue, implicating its potential role for the treatment of human DCM.
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| http://dx.doi.org/10.1159/000505408 | DOI Listing |
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