AI Article Synopsis
- Developments in nanomedicine over the past 20 years have led to advancements in using nanoparticles (NPs) in clinical science, with both organic and inorganic types showing safety and effectiveness.
- Protein nanoparticles are particularly notable for their biocompatibility and are now widely used in pharmaceutical applications across various delivery methods.
- The review focuses on recent research into protein NPs for oral delivery systems, highlighting their advantages and the challenges that still need to be addressed for effective development.
Article Abstract
Over the last two decades, developments in nanomedicine have resulted in technical advances with application to clinical science. Both organic and inorganic nanoparticles (NPs) have shown tolerability, pharmacologic specificity and biodegradability. A subclass of NPs, protein NPs, have garnered recent attention due to the inherent biocompatibility of protein substrates. Protein NPs are currently being employed widely in pharmaceuticals development with applications in nasal, pulmonary, intravenous, ocular and oral delivery. Despite the distinct advantages of orally administered pharmaceuticals, the development of oral delivery systems has been comparatively limited. Therefore, this review attempts to discuss the most recent experimental and pre-clinical findings in the development of protein NPs for oral delivery, while envisioning upcoming challenges.
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| http://dx.doi.org/10.1016/j.phrs.2020.104685 | DOI Listing |
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