AI Article Synopsis

  • The Dcc receptor is important for eye development but its exact role isn’t clear because mice without it don’t survive.
  • Researchers created a special type of mouse that only lacks Dcc in the eye to study its effects.
  • They discovered that without Dcc, some nerve cells in the eye didn’t connect properly and there was a significant loss of other important cells, showing Dcc is crucial for keeping our eyes healthy.

Article Abstract

The Deleted in Colorectal Carcinoma (Dcc) receptor plays a critical role in optic nerve development. Whilst Dcc is expressed postnatally in the eye, its function remains unknown as knockouts die at birth. To circumvent this drawback, we generated an eye-specific mutant. To study the organization of the retina and visual projections in these mice, we also established EyeDISCO, a novel tissue clearing protocol that removes melanin allowing 3D imaging of whole eyes and visual pathways. We show that in the absence of , some ganglion cell axons stalled at the optic disc, whereas others perforated the retina, separating photoreceptors from the retinal pigment epithelium. A subset of visual axons entered the CNS, but these projections are perturbed. Moreover, -deficient retinas displayed a massive postnatal loss of retinal ganglion cells and a large fraction of photoreceptors. Thus, Dcc is essential for the development and maintenance of the retina.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062470PMC
http://dx.doi.org/10.7554/eLife.51275DOI Listing

Publication Analysis

Top Keywords

revisiting role
4
dcc
4
role dcc
4
visual
4
dcc visual
4
visual system
4
system development
4
development novel
4
novel eye
4
eye clearing
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!