AI Article Synopsis
- Collagen is the biggest protein in animals and helps keep our bodies healthy, but if it doesn't work right, it can cause problems as we age.
- Scientists found a new gene that stops collagen from being made properly, which makes cells stressed out.
- They discovered that a part of a protein called TMEM131 helps gather and move collagen, making sure it gets to where it needs to go in our bodies.
Article Abstract
Collagen is the most abundant protein in animals. Its dysregulation contributes to aging and many human disorders, including pathological tissue fibrosis in major organs. How premature collagen proteins in the endoplasmic reticulum (ER) assemble and route for secretion remains molecularly undefined. From an RNA interference screen, we identified an uncharacterized gene , deficiency of which impairs collagen production and activates ER stress response. We find that amino termini of human TMEM131 contain bacterial PapD chaperone-like domains, which recruit premature collagen monomers for proper assembly and secretion. Carboxy termini of TMEM131 interact with TRAPPC8, a component of the TRAPP tethering complex, to drive collagen cargo trafficking from ER to the Golgi. We provide evidence that previously undescribed roles of TMEM131 in collagen recruitment and secretion are evolutionarily conserved in , , and humans.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015688 | PMC |
| http://dx.doi.org/10.1126/sciadv.aay7667 | DOI Listing |
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