AI Article Synopsis
- Dupuytren's contracture is frequently seen in older individuals in Sweden, and past studies revealed no significant differences between collagenase injections and needle fasciotomy treatments.
- A retrospective analysis was conducted comparing improvements in joint extension for patients treated with collagenase (71 fingers) and needle fasciotomy (109 fingers) one year post-treatment, assessing the metacarpophalangeal (MCP) and proximal interphalangeal joints.
- Results indicated that the collagenase group had a statistically significant greater improvement in MCP joint extension and a higher number of patients seeing considerable improvements, suggesting collagenase may be a more effective treatment option, although further prospective studies are needed for confirmation.
Article Abstract
Unlabelled: Dupuytren's contracture is common among older people in Sweden. Previous studies comparing the treatment with an injection of collagenase with percutaneous needle fasciotomy found no differences.
Methods: We retrospectively compared the degree of improvement in the deficit in extension of the joints in 2 groups of patients who had been treated with collagenase (71 fingers) or needle fasciotomy (109 fingers) before and 1 year after treatment. We compared the improvement of the extension deficit among the metacarpophalangeal (MCP) and proximal interphalangeal joints before and after the intervention; additionally, the level of improvement was classified into 3 levels (mild = 0° to 29°; moderate = 30° to 60°; considerable = 61° and more).
Results: The degree of improvement of extension in the MCP joints was 11° greater in the collagenase group ( = 0.001). The number of patients who had an improvement of >60° (considerable) in extension was greater in the collagenase group ( = 0.02).
Conclusion: Collagenase was more effective than needle fasciotomy in treating extension deficits of the MCP joints in Dupuytren's contracture in this retrospective analysis. Further prospective studies are required to confirm the finding.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015605 | PMC |
| http://dx.doi.org/10.1097/GOX.0000000000002606 | DOI Listing |
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