Reverse Sequence Syphilis Screening and Discordant Results in Pregnancy.

J Pediatr

Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH; Divisions of Neonatology and Pediatric Infectious Diseases, Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH. Electronic address:

Published: April 2020

A "reverse sequence syphilis screening" algorithm is widely used for syphilis testing. This retrospective study showed that most (65%) pregnant women with discordant screening results (treponemal multiplex flow immunoassay IgG+/rapid plasma reagin-) had a nonreactive confirmatory Treponema pallidum-particle agglutination assay, likely indicative of a false-positive reaction.

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Source
http://dx.doi.org/10.1016/j.jpeds.2019.11.035DOI Listing

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