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The Role of Pharmacotherapy for Smoking Cessation and Pregnancy.
Am J Lifestyle Med
January 2025
Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Tobacco and nicotine use is widely recognized as harmful to both the user and those exposed to the substances. Pregnant individuals face additional risks, with potential adverse outcomes for the fetus and newborn. A combination of behavioral and pharmacological interventions is recommended for smoking cessation; however, in pregnancy, there are additional considerations with the use of pharmacotherapy.
View Article and Find Full Text PDFNicotine levels in flavoured hookah (waterpipe) tobacco products: discrepancies between labelled and measured levels.
Tob Control
January 2025
University of California San Francisco, San Francisco, California, USA.
Background: Hookah tobacco smoking is prevalent among youth and young adults. While health warning labels play a critical role in communicating the health risks of tobacco product use to consumers, compliance with US Federal Regulation's nicotine warning requirements on hookah tobacco packaging is low. Some labelling suggests that consumers are exposed to 'only 0.
View Article and Find Full Text PDFEffects of E-Cigarette (e-cig) Aerosols on Mutagenesis in Selected Organs in a C57 (BigBlue) Mouse Model.
Int J Environ Res Public Health
December 2024
Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010, USA.
The objective of this study is to investigate the potential mutagenic effects of the exposure of mice to aerosols produced from the component liquids of an electronic nicotine delivery system (ENDS). The use of electronic cigarettes (e-cigs) and ENDSs has increased tremendously over the past two decades. From what we know to date, ENDSs contain much lower levels of known carcinogens than tobacco smoke.
View Article and Find Full Text PDFChronic nicotine exposure induces molecular and transcriptomic endophenotypes associated with mood and anxiety disorders in a cerebral organoid neurodevelopmental model.
Front Pharmacol
December 2024
Addiction Research Group, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Introduction: Prenatal nicotine exposure (PNE) from maternal smoking disrupts regulatory processes vital to fetal development. These changes result in long-term behavioral impairments, including mood and anxiety disorders, that manifest later in life. However, the relationship underlying PNE, and the underpinnings of mood and anxiety molecular and transcriptomic phenotypes remains elusive.
View Article and Find Full Text PDFAdult neurogenesis in the ventral hippocampus decreased among animal models of neurodevelopmental disorders.
Front Neural Circuits
January 2025
Department of Molecular and Cellular Physiology, Shinshu University School of Medicine, Matsumoto, Japan.
Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social interaction and communication, along with restricted and repetitive behaviors. Both genetic and environmental factors contribute to ASD, with prenatal exposure to valproic acid (VPA) and nicotine being linked to increased risk. Impaired adult hippocampal neurogenesis, particularly in the ventral region, is thought to play a role in the social deficits observed in ASD.
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