https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=32093783&retmode=xml&tool=Litmetric&email=readroberts32@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09 320937832020112420201124
1478-63622212020Feb24Arthritis research & therapyArthritis Res TherSeasonal effect on fatigue, pain and dryness in primary Sjögren's syndrome.39393910.1186/s13075-020-2118-1To assess the presence of a seasonal effect on fatigue, pain and dryness in primary Sjögren's syndrome (pSS).Data (date; visual analogue scales (VAS) for pain, fatigue and dryness) were extracted from three randomised placebo-controlled trials (RCTs) evaluating infliximab (TRIPSS; n = 103 patients), hydroxychloroquine (JOQUER; n = 120 patients) and rituximab (TEARS; n = 120 patients) and from the 5-year follow-up of the ASSESS prospective cohort (n = 395 patients). Data were analysed at each visit for each patient, according to the day, the month of the year and the season. Linear mixed models were used to take into account the repeated structure of the data and to analyse a potential cyclic effect.A total of 744, 584, 848 and 682 pain, fatigue and dryness VASs were collected on 632 subjects in spring, summer, fall and winter, respectively. No significant difference was observed in pain, fatigue and dryness, according to the month of the year or the season (all p values > 0.05).In pSS, seasonality does not affect patient-reported outcomes (PROs) on fatigue, pain and dryness.DuretPierre-MariePM0000-0003-1070-8830Department of Rheumatology, Colmar General Hospital, Colmar, France. pierre-marie.duret@ch-colmar.fr.MeyerNicolasNDepartment of Public Health, GMRC, Strasbourg University Hospital, Strasbourg, France.SarauxAlainADepartment of Rheumatology, Brest University Hospital, Brest, France.Devauchelle-PensecValérieVDepartment of Rheumatology, Brest University Hospital, Brest, France.SerorRaphaeleRCenter for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique - Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, INSERM, Paris, France.Le-GuernVéroniqueVDepartment of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP-HP, Université Paris Descartes, Paris, France.LarrocheClaireCDepartment of internal Medicine, Avicenne Hospital, Bobigny, France.PerdrigerAlethADepartment of Rheumatology, Rennes University Hospital, Rennes, France.SibiliaJeanJDepartment of Rheumatology, Referral Center for Rare Autoimmune and Systemic Diseases, Strasbourg University Hospital, Strasbourg, France.GuardiolleVianneyVDepartment of Public Health, GMRC, Strasbourg University Hospital, Strasbourg, France.MarietteXavierXCenter for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique - Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, INSERM, Paris, France.GottenbergJacques-EricJEDepartment of Rheumatology, Referral Center for Rare Autoimmune and Systemic Diseases, Strasbourg University Hospital, Strasbourg, France.CNRS, Immunopathologie et Chimie Thérapeutique/Laboratory of Excellence Medalis, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.engJournal ArticleResearch Support, Non-U.S. Gov't20200224
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