The alpha-glucosidase- and lipase-inhibitory activities of three phenalenones (-) and one phenylpropanoid () from the ethyl acetate extracts of a sp. are described. They represent the first secondary metabolites reported from the genus . Scleroderolide () and sclerodione () exhibited potent α-glucosidase- and porcine-lipase-inhibitory activity during primary screening, with better IC values compared to the positive controls, N-deoxynojirimycin and orlistat. In silico techniques were employed to validate the probable biological targets and elucidate the mechanism of actions of phenalenones and . Both compounds exhibited strong binding affinities to both alpha-glucosidase and porcine lipase through H-bonding and π-π interactions. Interestingly, favorable in silico ADME (absorption, distribution, metabolism, and excretion) properties such as gastrointestinal absorption were also predicted using software.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070682 | PMC |
| http://dx.doi.org/10.3390/molecules25040965 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Impact of Cooking on Antioxidant and Enzyme Activities in Ruichang Yam Polyphenols.
Foods
December 2024
Jiangxi Ecological Chemical Engineering Technology Research Center, Jiujiang University, Jiujiang 332005, China.
In this study, the total polyphenol content (TPC), total flavonoid content (TFC), and biological activity of yam polyphenols (including free phenolics, conjugated phenolics, and bound phenolics) were investigated during home cooking. Polyphenol components were preliminary detected in raw yam by HPLC, including 2, 4-dihydroxybenzoic acid, syringic acid, vanillic acid, 4-coumaric acid, and sinapic acid. TPC and TFC of soluble conjugated polyphenols were the main phenolic compounds in Ruichang yam.
View Article and Find Full Text PDFMetabolomics Characterization of Chemical Composition and Bioactivity of Highland Barley Monascus Tea Decoction Before and After Simulated Digestion In Vitro.
Foods
December 2024
Key Laboratory of Agricultural Product Processing on Qinghai-Tibetan Plateau, College of Agricultural and Forestry Sciences, Qinghai University, Xining 810000, China.
A broadly targeted metabolomics approach based on UPLC-MS/MS was employed to investigate the changes in chemical composition and in vitro activity of highland barley Monascus tea decoction before and after simulated digestion. The characteristic metabolites of the tea decoction before and after in vitro-simulated digestion were identified, and the in vitro antioxidant and enzyme inhibitory activities of the tea decoction were further analyzed. The study detected 1431 metabolites, including amino acids and their derivatives, alkaloids, organic acids, nucleotides and their derivatives, lipids, terpenoids, and phenolic acids.
View Article and Find Full Text PDFExploring the nutritional and biological properties of green coffee extracts: A comparative study of aqueous and enzymatic extraction processes.
Curr Res Food Sci
October 2024
Department of Food Science and Technology, University of California, Davis, One Shields Avenue, Davis, CA, 95616, United States.
Article Synopsis
- - The study examined how aqueous extraction processes (AEP) and enzyme-assisted aqueous extraction processes (EAEP) affect the nutritional and biological properties of green coffee extracts, focusing on protein digestibility and antioxidant content.
- - Increasing the extraction pH to 9.0 decreased levels of caffeine and certain phenolic compounds, resulting in lower antioxidant activity, while pH 7.0 yielded better overall extract quality with higher phenolic compounds and lipase inhibitory activity.
- - EAEP extracts showed stronger inhibition of angiotensin-converting enzyme than AEP extracts, indicating that both extraction methods can be optimized to enhance specific health-related properties of green coffee extracts sustainably.
Unraveling the Impact of -A Food-Grade Fungus-On Phytoalexins, Phenolic Acids, and the Antioxidant and Antidiabetic Activity of Different Legumes.
Foods
November 2024
Southern Regional Research Center, Agricultural Research Service, U. S. Department of Agriculture, New Orleans, LA 70124, USA.
Legumes are a rich source of polyphenolic compounds known for their ability to promote health. Under stress conditions, legumes have been shown to produce higher levels of secondary metabolites, as a defensive mechanism. Hence, the present study aimed to induce legume seeds (e.
View Article and Find Full Text PDFCarob pulp flour as an innovative source of bioactive molecules for the preparation of high-value-added jellies.
Heliyon
October 2024
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
The rising demand for healthier alternatives to traditional sugary products has driven the exploration of natural substitutes for sucrose. This study aimed to investigate carob pulp flour (CPF) as a viable alternative to sucrose in the production of high-value jellies with enhanced health benefits. Carob pulp flour was spectroscopically characterized, revealing the presence of bioactive molecules, such as natural antidiabetic polyols and polyphenols.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!