AI Article Synopsis
- A study on a fungus (strain S003) from Red Sea sediment resulted in the isolation of a new cerebroside molecule and three known compounds: ergosterol, epidioxyergosterol, and kojic acid.
- The structures of these compounds were determined using advanced techniques such as 1D and 2D NMR and mass spectrometry.
- The cytotoxic effects of the isolated compounds were tested against five cancer cell lines, with two of them showing significant activity against lung, prostate, breast, and liver cancers, while they were inactive against HeLa cells and had weak effects overall.
Article Abstract
Chemical investigation of the ethyl acetate extract of strain S003, a fungus isolated from Red Sea deep sediment, led to the isolation of a cerebroside molecular species LAMA () along with three other known compounds, ergosterol (), epidioxyergosterol (), and kojic acid (). The structures of the isolated compounds were elucidated by interpretation of spectral data, including detailed 1D and 2D NMR (One and two dimensional Nuclear Magnetic Resonance) and mass spectrometry. The cytotoxic activities of isolated compounds - against five human carcinoma cells were evaluated using sulforhodamine B (SRB) assay. Compounds and displayed promising cytotoxic profiles against lung cancer (A-549), prostate (DU-145), breast adenocarcinoma (MCF-7), and hepatocellular (HepG2) cell lines, with IC values of 21.26, 19.3; 1.50, 6.10; 16.95, 13.6; and 2.89, 3.07 µM, respectively, while they were inactive against HeLa cells. Compounds and showed weak cytotoxic profiles against all cell lines under investigation.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074484 | PMC |
| http://dx.doi.org/10.3390/metabo10020075 | DOI Listing |
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