Achieving the UN Sustainable Development Goals depends on using resources efficiently, avoiding fragmentation in decision-making, recognising the trade-offs and synergies across sectors and adopting an integrated Nexus thinking among policymakers. Nexus Informatics develops the science of recognising and quantifying nexus interlinkages. Nexus-coherent solutions enhance the effect of policymaking in achieving adequate governance, leading to successful strategic vision and efficient resource management. In this article, we present the structure of a System Dynamics Model-the Nexus_SDM-that maps sector-specific data from major databases (e.g., EUROSTAT) and scenario models (e.g., E3ME-FTT OSeMOSYS and SWIM) for the national case study of Greece. Disaggregation algorithms are employed on annual national-scale data, turning them into detailed spatial and temporal datasets, by converting them to monthly values spread among all 14 River Basin Districts (RBDs). The Nexus_SDM calculates Nexus Interlinkage Factors and quantifies interlinkages among Water, Energy, Food, Built Environment, Natural Land and greenhouse gas (GHG) emissions. It simulates the nexus in the national case study of Greece as a holistic multi-sectoral system and provides insights into the vulnerability of resources to future socio-economic scenarios. It calculates the link between crop type/area, irrigation water and agricultural value, revealing which crops have the highest agricultural value with the least water and crop area. It demonstrates that fossil fuel power generation and use of oil for transportation are responsible for the most GHG emissions in most RBDs and presents projections for years 2030 and 2050. The analysis showcases that to move from a general nexus thinking to an operational nexus concept, it is important to focus on data availability and scale. Advanced Sankey and Chord diagrams are introduced to show distribution of resource use among RBDs and an innovative visualisation tool is developed, the Nexus Directional Chord plot, which reveals Nexus hotspots and strong interlinkages among sectors, facilitating stakeholder awareness.
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http://dx.doi.org/10.1016/j.scitotenv.2020.137264 | DOI Listing |
Curr Top Dev Biol
January 2025
Department of Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, OH, United States.
Alterations in tissue expression levels of both retinol-binding protein 2 (RBP2) and retinol-binding protein 4 (RBP4) have been associated with metabolic disease, specifically with obesity, glucose intolerance and hepatic steatosis. Our laboratories have shown that this involves novel pathways not previously considered as possible linkages between impaired retinoid metabolism and metabolic disease development. We have established both biochemically and structurally that RBP2 binds with very high affinity to very long-chain unsaturated 2-monoacylglycerols like the canonical endocannabinoid 2-arachidonoyl glycerol (2-AG) and other endocannabinoid-like substances.
View Article and Find Full Text PDFMagn Reson Med
January 2025
Department 8.1 - Biomedical Magnetic Resonance, Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.
Purpose: To develop a low-cost, high-performance, versatile, open-source console for low-field MRI applications that can integrate a multitude of different auxiliary sensors.
Methods: A new MR console was realized with four transmission and eight reception channels. The interface cards for signal transmission and reception are installed in PCI Express slots, allowing console integration in a commercial PC rack.
Eur J Trauma Emerg Surg
January 2025
Emergency Department, Tel Aviv Sourasky Medical Center, 6 Weizman Street, 6423906, Tel Aviv, Israel.
Objective: To evaluate the NEXUS Chest CT ALL decision instrument (DI) in reducing unnecessary chest CT imaging in minor blunt trauma patients while preserving high sensitivity for detecting clinically meaningful injuries. Additionally, we examined the impact of delayed presentation, chronic disease, and anticoagulation/anti-aggregation medications on trauma outcomes.
Methods: This retrospective study included 853 adult minor blunt trauma patients who underwent chest CT in the emergency department (ED) of Tel-Aviv Sourasky Medical Center between 2018 and 2022.
Invest Ophthalmol Vis Sci
January 2025
GROW Research Laboratory, Narayana Netralaya Foundation, Bangalore, India.
Purpose: Keratoconus (KC) is characterized by irregular astigmatism along with corneal stromal weakness and is associated with altered immune status. Tissue resident microbiomes are known to influence the immune status in other organs, but such a nexus has not been described in ocular conditions. Therefore, we examined the ocular surface microbiome of patients with KC and correlated it to the immune cell and tear molecular factor profiles.
View Article and Find Full Text PDFJ Hum Nutr Diet
February 2025
Centre for Community Health and Wellbeing, The University of Queensland, Brisbane, Queensland, Australia.
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