The ability to respire and generate adenosine triphosphate (ATP) is essential for the physiology, persistence, and pathogenicity of , which causes tuberculosis. By employing a lead repurposing strategy, the malarial cytochrome inhibitor SCR0911 was tested against mycobacteria. Docking studies were carried out to reveal potential binding and to understand the binding interactions with the target, cytochrome . Whole-cell-based and assays demonstrated the potency of SCR0911 by inhibiting cell growth and ATP synthesis in both the fast- and slow-growing and bacillus Calmette-Guérin, respectively. The variety of biochemical assays and the use of a cytochrome deficient mutant strain validated the cytochrome oxidase as the direct target of the drug. The data demonstrate the broad-spectrum activity of SCR0911 and open the door for structure-activity relationship studies to improve the potency of new mycobacteria specific SCR0911 analogues.
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http://dx.doi.org/10.1021/acsinfecdis.9b00408 | DOI Listing |
Naturwissenschaften
January 2025
Centre for Climate Change Studies, Sathyabama Institute of Science and Technology, Tamil Nadu, Rajiv Gandhi Salai, Chennai, 600119, India.
The seagrass ecosystem supports a diverse range of marine life, including fish, crabs, and seahorses. It plays a vital role in providing essential services such as habitat creation, nutrient cycling, and shoreline stabilization. In the present study, we conducted line intercept transects to assess the abundance of Pinna shells in seagrass meadows of the Sangumal region in the Palk Bay, India.
View Article and Find Full Text PDFDalton Trans
January 2025
CLIC, Institut de Chimie de Strasbourg, UMR 7177 CNRS-Unistra, 4 rue Blaise Pascal, 67000 Strasbourg, France.
Iron-copper complexes have been extensively studied in the search for efficient cytochrome oxidase models. Whereas most dinuclear materials usually focus on fine-tuning the coordination of heme-Fe, this work shows that the coordination of copper in cytochrome oxidase models should be carefully taken into consideration. A β-cyclodextrin dimer was built around a bipyridine linker and combined with Fe-tetraphenylsulfonatoporphyrinate (FeTPPS) to generate a self-assembled hydrosoluble cytochrome oxidase model.
View Article and Find Full Text PDFMol Biol Rep
January 2025
College of Marine Living Resource Sciences and Management, Shanghai Ocean University, Shanghai, 201306, China.
Background: Uroteuthis edulis is a significant economic cephalopod resource utilized by mainland China, Taiwan, and Japan. Understanding the population genetic structure of U.edulis is essential to evaluate the changes of its resource abundance.
View Article and Find Full Text PDFInvertebr Syst
January 2025
Instituto de Biología, UNAM, Departamento de Zoología, Colección Nacional de Insectos, Apartado Postal 70-153, 04510, Ciudad de México, Mexico.
The superfamily Mantispoidea (Insecta: Neuroptera) includes the families Berothidae, Rhachiberothidae and Mantispidae. Among these taxa, the last two are collectively known as Raptorial Mantispoidea due to the presence of grasping forelegs for predatory habits. The Mantispidae classically included the subfamilies Symphrasinae, Drepanicinae, Calomantispinae and Mantispinae, yet recent research challenged this classification scheme as well as the monophyly of this family resulting in Symphrasinae being transferred to Rhachiberothidae.
View Article and Find Full Text PDFJ Helminthol
January 2025
Department of Parasitology, Faculty of Veterinary Medicine, University of Firat, 23119, Elazig, Türkiye.
The primary definitive host of the giant acanthocephalan, also known as the giant thorny-headed worm (Pallas, 1781), is . The definitive host ingests the parasite by consuming infected scarabaeoid or hydrophilid beetles. This study aimed to ascertain the presence of in the intermediate hosts through molecular analysis.
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