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Development and validation of a VP7-specific EIA for determining the potency and stability of inactivated rotavirus vaccine.
J Virol Methods
February 2025
Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address:
Article Synopsis
- Researchers developed a new enzyme immunoassay (EIA) to evaluate the potency of inactivated rotavirus vaccines using a specific monoclonal antibody that targets RV VP7, a crucial protein for vaccine efficacy.
- The EIA demonstrated excellent specificity and accuracy, with a low detection limit, making it reliable for assessing the stability and potency of the vaccine under different storage conditions.
- This assay could replace animal testing for potency checks, providing a feasible quality control method for clinical trials involving inactivated rotavirus vaccine lots.
Novel platform for engineering stable and effective vaccines against botulinum neurotoxins A, B and E.
Front Immunol
September 2024
School of Biotechnology, Dublin City University, Dublin, Ireland.
Botulinum neurotoxin (BoNT), produced by , is the most toxic protein known, capable of causing severe paralysis and posing a significant bioterrorism threat due to its extreme lethality even in minute quantities. Despite this, there are currently no FDA-approved vaccines for widespread public use. To address this urgent need, we have developed an innovative vaccine platform by fusing the neuronal binding domain of BoNT/E (Hc/E) with core-streptavidin (CS), resulting in a stable CS-Hc/E vaccine.
View Article and Find Full Text PDFDevelopment and characterization of a multimeric recombinant protein using the spike protein receptor binding domain as an antigen to induce SARS-CoV-2 neutralization.
Immun Inflamm Dis
July 2024
Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.
Background: SARS-CoV2 virus, responsible for the COVID-19 pandemic, has four structural proteins and 16 nonstructural proteins. S-protein is one of the structural proteins exposed on the virus surface and is the main target for producing neutralizing antibodies and vaccines. The S-protein forms a trimer that can bind the angiotensin-converting enzyme 2 (ACE2) through its receptor binding domain (RBD) for cell entry.
View Article and Find Full Text PDFExpression of dengue capsid-like particles in silkworm and display of envelope domain III of dengue virus serotype 2.
Protein Expr Purif
October 2024
Department of Bioscience, Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan. Electronic address:
Dengue virus (DENV) is a considerable public health threat affecting millions of people globally. Vaccines for dengue are an important strategy to reduce the disease burden. We expressed capsid (C2) and envelope domain III of dengue virus serotype 2 (2EDIII) separately in the silkworm expression system.
View Article and Find Full Text PDFGlutathione-activated biotin-targeted dual-modal imaging probe with improved PDT/PTT synergistic therapy.
Anal Chim Acta
August 2024
Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, Hunan Provincial University Key Laboratory for Environmental and Ecological Health, College of Chemistry, Xiangtan University, Xiangtan, 411105, PR China. Electronic address:
Background: Glutathione (GSH), a highly abundant thiol compound within cells, plays a critical role in physiological processes and exhibits close correlation with cancer. Among molecular imaging technologies, most probes have relatively short emission wavelengths and lack photoacoustic imaging (PA) capability, resulting in the inability to obtain tissue images with high penetration depth. The presence of GSH in the tumor microenvironment neutralizes ROS, diminishing the therapeutic effect of PDT, thus resulting in often unsatisfactory therapeutic efficacy.
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