Glycolipid-mediated basophil activation in alpha-gal allergy.

Onyinye I Iweala Shailesh K Choudhary Claire T Addison Cole J Batty Camille M Kapita Claire Amelio Alexander J Schuyler Shenglou Deng Eric M Bachelder Kristy M Ainslie Paul B Savage Patrick J Brennan Scott P Commins

J Allergy Clin Immunol

Department of Medicine, Thurston Arthritis Research Center, Division of Rheumatology, Allergy, and Immunology, Chapel Hill, NC; Department of Pediatrics, University of North Carolina Food Allergy Initiative, Division of Allergy, Immunology and Rheumatology, Chapel Hill, NC.

Published: August 2020

Alpha-gal-containing glycolipids activate basophils sensitized with plasma from alpha-gal allergic subjects in an IgE-dependent manner suggesting a role for glycolipid in the effector phase of IgE-mediated food allergy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670280	PMC
http://dx.doi.org/10.1016/j.jaci.2020.02.006	DOI Listing

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