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Linear ubiquitination at damaged lysosomes induces local NFKB activation and controls cell survival.
Autophagy
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Institute for Experimental Pediatric Hematology and Oncology, Goethe University Frankfurt, Frankfurt am Main, Germany.
Lysosomes are the major cellular organelles responsible for nutrient recycling and degradation of cellular material. Maintenance of lysosomal integrity is essential for cellular homeostasis and lysosomal membrane permeabilization (LMP) sensitizes toward cell death. Damaged lysosomes are repaired or degraded via lysophagy, during which glycans, exposed on ruptured lysosomal membranes, are recognized by galectins leading to K48- and K63-linked poly-ubiquitination (poly-Ub) of lysosomal proteins followed by recruitment of the macroautophagic/autophagic machinery and degradation.
View Article and Find Full Text PDFPortable astronomical observation system based on large-aperture concentric-ring metalens.
Light Sci Appl
January 2025
Institute of Microstructure Technology (IMT), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtzplatz 1, Eggenstein-Leopoldshafen, 76344, Germany.
The core advantage of metalenses over traditional bulky lenses lies in their thin volume and lightweight. Nevertheless, as the application scenarios of metalenses extend to the macro-scale optical imaging field, a contradiction arises between the increasing demand for large-aperture metalenses and the synchronous rise in design and processing costs. In response to the application requirements of metalens with diameter reaching the order of 10λ or even 10λ, this paper proposes a novel design method for fixed-height concentric-ring metalenses, wherein, under the constraints of the processing technology, a subwavelength 2D building unit library is constructed based on different topological structures, and the overall cross-section of the metalens is assembled.
View Article and Find Full Text PDFBilateral internal superior laryngeal nerve injections for unexplained chronic cough.
Am J Otolaryngol
December 2024
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, United States of America. Electronic address:
Objective: Internal Superior laryngeal nerve (iSLN) injections with steroids and anesthetic for Unexplained Chronic Cough (UCC) was initially described as a unilateral injection. This study reports the safety profile and patient-reported outcomes of concurrent bilateral iSLN injections for UCC.
Study Design: Retrospective chart review.
Two Alkaline Metal Borates: from Layer to Layer-Pillared Framework.
Inorg Chem
December 2024
MOE Key Laboratory of Cluster Science, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 102488, China.
Two borates, NaK[BO(OH)]·HO () and NaK[{BO}{BO}{BO(OH)}]·2HO () have been designed and made under solvothermal conditions. Compound exhibits a 2D fluctuant layer based on the [BO(OH)] clusters, containing two types of 9-membered ring (MR) channels and showing a four-connected sql topology net. By modifying the reactants and reaction temperature, compound was obtained from compound .
View Article and Find Full Text PDFMetaplastic breast cancer (MpBC) is a highly chemoresistant subtype of breast cancer with no standardized therapy options. A clinical study in anthracycline-refractory MpBC patients suggested that nitric oxide synthase (NOS) inhibitor NG-monomethyl-l-arginine (L-NMMA) may augment anti-tumor efficacy of taxane. We report that NOS blockade potentiated response of human MpBC cell lines and tumors to phosphoinositide 3-kinase (PI3K) inhibitor alpelisib and taxane.
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