pH-sensitive CuS@CuS@Au nanoparticles (NPs) are successfully prepared by sacrificing template method. The NPs are of hollow structure, which is certified by transmission electron microscopy (TEM). The CuS@CuS@Au NPs can be used as carriers for doxorubicin (DOX). The DOX loaded NPs exhibit pH-sensitive release of the drug, which are prospective as controllable drug delivery system. Besides, relative to the high toxicity and lethality of the free DOX, the time-dependent release of drug from the NPs is more suitable for the long-time and lasting treatment for colon cancer. The CuS@CuS@Au NPs with good biocompatibility are promising biomaterials in the application of biomedical and tissue engineering fields.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbrc.2020.01.097 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Programmable Food-Derived Peptide Coassembly Strategies for Boosting Targeted Colitis Therapy by Enhancing Oral Bioavailability and Restoring Gut Microenvironment Homeostasis.
ACS Nano
January 2025
Jilin Provincial Key Laboratory of Nutrition and Functional Food, College of Food Science and Engineering, Jilin University, Changchun 130062, China.
Orally targeting nanostrategies of multiple nutraceuticals have attracted increasing attention in ulcerative colitis (UC) therapy for superior patient compliance, cost-effectiveness, and biocompatibility. However, the actual targeting delivery and bioefficacy of nutraceuticals are extremely restricted by their poor solubility, interior gastrointestinal retention, and base permeability. Herein, we developed controllable colon-targeting nanoparticles (NPs) composed of a quaternary ammonium chitosan (HTCC) shell and succinic acid-modified γ-cyclodextrin (SACD) core for precise UC treatment.
View Article and Find Full Text PDFA new biocompatible COF-MCM nanoporous hybrid DDS for pH-controlled delivery of curcumin.
Sci Rep
December 2024
Department of Biology, Faculty of Science, University of Guilan, P.O. Box 1914, Rasht, Iran.
A novel polyimide-bridge covalent organic framework-based (PI-COF) hybrid was synthesized through simple green chemistry between PI-COF and MCM-NH monomers as a pH-sensitive anticancer curcumin (C) delivery system. The synthesized nanohybrid was crystalline in nature with an improved surface area and pore volume compared to the base COF, certified by powder X-ray diffraction spectroscopy and Brunauer-Emmett-Teller technique. Kinetically controlled and sustained curcumin release profiles were investigated using the as-prepared curcumin-loaded drug delivery systems (C@DDSs) in neutral and acidic pH media.
View Article and Find Full Text PDFNoncanonical calcium binding motif controls folding of HopQ1, a Pseudomonas syringae type III secretion effector, in a pH-dependent manner.
Sci Rep
December 2024
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Virulence of many gram-negative bacteria relies upon delivery of type three effectors into host cells. To pass through the conduit of secretion machinery the effectors need to acquire an extended conformation, and in many bacterial species specific chaperones assist in this process. In plant pathogenic bacterium Pseudomonas syringae, secretion of only few effectors requires the function of chaperones.
View Article and Find Full Text PDFpH-sensitive chitosan/sodium alginate/calcium chloride hydrogel beads for potential oral delivery of rice bran bioactive peptides.
Food Chem
December 2024
Molecular Nutrition Branch, National Engineering Research Center of Rice and By-product Deep Processing/College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan 410004, China. Electronic address:
Although rice bran active peptide (RBAP) has potent antioxidant properties, its practical applications have been limited by its low bioavailability. In this study, we hypothesized that pH-responsive hydrogels prepared from the ionic gelation between chitosan and alginate could be a promising delivery system of short-chain peptides, like RBAP, for protecting them from chemical degradation during digestion and improving their functionality. The hydrogel beads retained RBAP in the gastric environment due to strong interactions between two biopolymers and RBAP, followed by a sustained release of more than 70 % peptide in the intestinal condition, thus improving its gastrointestinal stability.
View Article and Find Full Text PDFInjectable and 3D-Printable Semi-Interpenetrating Polymer Networks Based on Modified Sodium Alginate for Cell Spheroid Formation.
Biomacromolecules
December 2024
Department of Chemical Engineering, University of Patras, Patras 26504, Greece.
We report on 3D-printable polymer networks based on the combination of modified alginate-based polymer blends; two alginate polymers were prepared, namely, a thermoresponsive polymer grafted with P(NIPAM--NtBAM)-NH copolymer chains and a second polymer modified with diol/pH-sensitive 3-aminophenylboronic acid. The gelation properties were determined by the hydrophobic association of the thermosensitive chains and the formation of boronate esters. At a mixing ratio of 70/30 wt % of the thermo/diol-responsive polymers, the semi-interpenetrating network exhibited an optimum storage modulus ranging from ca.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!