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Antibody reactions of horses against various domains of the EHV-1 receptor-binding protein gD1.
PLoS One
July 2024
Institute of Virology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Equid alphaherpesviruses 1 (EHV-1) and 4 (EHV-4) are closely related and both endemic in horses worldwide. Both viruses replicate in the upper respiratory tract, but EHV-1 may additionally lead to abortion and equine herpesvirus myeloencephalopathy (EHM). We focused on antibody responses in horses against the receptor-binding glycoprotein D of EHV-1 (gD1), which shares a 77% amino acid identity with its counterpart in EHV-4 (gD4).
View Article and Find Full Text PDFEstablishment of a Three-Dimensional In Vitro Model of Equine Papillomavirus Type 2 Infection.
Viruses
July 2021
Institute of Virology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
There is growing evidence that equine papillomavirus type 2 (EcPV2) infection is etiologically associated with the development of genital squamous cell carcinoma (SCC) and precursor lesions in equids. However, the precise mechanisms underlying neoplastic progression remain unknown. To allow the study of EcPV2-induced carcinogenesis, we aimed to establish a primary equine cell culture model of EcPV2 infection.
View Article and Find Full Text PDFViral infections shared between water buffaloes and small ruminants in Switzerland.
J Vet Diagn Invest
September 2021
Institute of Virology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Importation of exotic animals that may harbor infectious agents poses risks for native species with potentially severe impacts on animal health and animal production. Although the Asian water buffalo () population in Europe is steadily increasing, its susceptibility to viral infections and its role for interspecies transmission is largely unknown. To identify viral infections that are shared between exotic water buffaloes and native small ruminants, we collected blood samples from 3 Swiss farms on which water buffaloes were kept either without, or together with, sheep or goats.
View Article and Find Full Text PDFMammalian orthoreovirus core protein μ2 reorganizes host microtubule-organizing center components.
Virology
October 2020
Institute of Virology, University of Zurich, Winterthurerstrasse 266a, 8057 Zurich, Switzerland. Electronic address:
Filamentous mammalian orthoreovirus (MRV) viral factories (VFs) are membrane-less cytosolic inclusions in which virus transcription, replication of dsRNA genome segments, and packaging of virus progeny into newly synthesized virus cores take place. In infected cells, the MRV μ2 protein forms punctae in the enlarged region of the filamentous VFs that are co-localized with γ-tubulin and resistant to nocodazole treatment, and permitted microtubule (MT)-extension, features common to MT-organizing centers (MTOCs). Using a previously established reconstituted VF model, we addressed the functions of MT-components and MTOCs concerning their roles in the formation of filamentous VFs.
View Article and Find Full Text PDFMathias Ackermann and Jean-Michel Hatt respond.
Vet Rec
February 2020
Institute of Veterinary Virology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
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