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Loss of cerebellar function selectively affects intrinsic rhythmicity of eupneic breathing. | LitMetric

AI Article Synopsis

  • Respiration is managed by brain stem circuits that can adjust breathing based on the body's needs, with the cerebellum playing a role during breathing challenges but not in normal breathing.
  • A study used a measure called CV2 to assess rhythmicity in breathing, finding that mice with cerebellar ataxia showed less variability in their breathing patterns compared to healthy mice, despite having similar average breathing rates.
  • The authors suggest that the cerebellum may help fine-tune the timing of breathing intervals to sync with other mouth movements like licking and swallowing.

Article Abstract

Respiration is controlled by central pattern generating circuits in the brain stem, whose activity can be modulated by inputs from other brain areas to adapt respiration to autonomic and behavioral demands. The cerebellum is known to be part of the neuronal circuitry activated during respiratory challenges, such as hunger for air, but has not been found to be involved in the control of spontaneous, unobstructed breathing (eupnea). Here we applied a measure of intrinsic rhythmicity, the CV2, which evaluates the similarity of subsequent intervals and is thus sensitive to changes in rhythmicity at the temporal resolution of individual respiratory intervals. The variability of intrinsic respiratory rhythmicity was reduced in a mouse model of cerebellar ataxia compared to their healthy littermates. Irrespective of that difference, the average respiratory rate and the average coefficient of variation (CV) were comparable between healthy and ataxic mice. We argue that these findings are consistent with a proposed role of the cerebellum in modulating the duration of individual respiratory intervals, which could serve the purpose of coordinating respiration with other rhythmic orofacial movements, such as fluid licking and swallowing.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197709PMC
http://dx.doi.org/10.1242/bio.048785DOI Listing

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