In the current issue of Molecular Cell, Liu et al. (2020) show that the secretion of cancer-linked forms of mutant calreticulin allow cancer cells to escape protective immune responses induced by chemotherapeutic and immunotherapeutic drugs, thereby promoting tumor growth.
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http://dx.doi.org/10.1016/j.molcel.2020.01.024 | DOI Listing |
Curr Res Parasitol Vector Borne Dis
November 2024
Unit of Vector Ecology, Pasteur Institute of Tunis, Tunis, Tunisia.
The taxa and are sympatric in Tunisia. The genetics underlying their morphological differences are unresolved. In this study, ticks collected in Jouza-Amdoun, Tunisia, were morphologically identified and sequenced using Oxford Nanopore Technologies.
View Article and Find Full Text PDFFront Plant Sci
October 2024
Plant Genetics Department, NIAB, Cambridge, United Kingdom.
Background: Root hairs are single-celled projections on root surfaces, critical for water and nutrient uptake. Here, we describe the first short root hair mutant in wheat ( L.), identified in a mutagenized population and termed here short root hair 1 ().
View Article and Find Full Text PDFCell Calcium
December 2024
Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton T6G2H7, Alberta, Canada. Electronic address:
Endoplasmic reticulum (ER) stress is triggered upon the interference with oxidative protein folding that aims to produce fully folded, disulfide-bonded and glycosylated proteins, which are then competent to exit the ER. Many of the enzymes catalyzing this process require the binding of Ca ions, including the chaperones BiP/GRP78, calnexin and calreticulin. The induction of ER stress with a variety of drugs interferes with chaperone Ca binding, increases cytosolic Cathrough the opening of ER Ca channels, and activates store-operated Ca entry (SOCE).
View Article and Find Full Text PDFInt J Nanomedicine
October 2024
Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210008, People's Republic of China.
Front Microbiol
September 2024
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.
Introduction: Human respiratory syncytial virus (hRSV) is a main cause of bronchiolitis in infants and its persistence has been described in immunocompromised subjects. However, limited evidence has been reported on the gene expression triggered by the hRSV and the effect of recombinant -derived calreticulin (rTsCRT).
Methods: Using a comprehensive microarray approach, we analyzed the transcriptome profile of a macrophage cell line that has supported hRSV persistence for over 150 passages.
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