A Calreticulin Tail: C-terminal Mutants of Calreticulin Allow Cancer Cells to Evade Phagocytosis.

Mol Cell

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Published: February 2020

In the current issue of Molecular Cell, Liu et al. (2020) show that the secretion of cancer-linked forms of mutant calreticulin allow cancer cells to escape protective immune responses induced by chemotherapeutic and immunotherapeutic drugs, thereby promoting tumor growth.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594649PMC
http://dx.doi.org/10.1016/j.molcel.2020.01.024DOI Listing

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