[Purpose] To examine the validity of the predictive formulas based on the angle information of the segment center of mass and moments of inertia, and to propose a joint moment estimation method. [Participants and Methods] Twenty nine young healthy adults were divided into two groups: the Creation group (20 adults) was needed to create the prediction formulas, and the Verification group (9 adults) was needed to verify the formulas. By monitoring the Creation group, the angular information from inertial motion sensors and moments of inertia of each limb were used to estimate actual ankle joint moment and knee joint moment. Thereafter, the actual joint moments was derived from the Verification group and compared to the predicted values via Pearson correlations. [Results] Good to excellent correlations were obtained between the actual joint moments of the two groups for most of the motions. [Conclusion] It is suggested that the predictive formulas created from the angle information of the segment center of mass and moments of inertia can be used for an approximate estimation of the lower limb joint moments in the sagittal plane and more clinically useful tools need to be considered in the future.
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http://dx.doi.org/10.1589/jpts.32.27 | DOI Listing |
J Virol
January 2025
SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg, South Africa.
The Antibody Mediated Prevention (AMP) trials showed that passively infused VRC01, a broadly neutralizing antibody (bNAb) targeting the CD4 binding site (CD4bs) on the HIV-1 envelope protein (Env), protected against neutralization-sensitive viruses. We identified six individuals from the VRC01 treatment arm with multi-lineage breakthrough HIV-1 infections from HVTN703, where one variant was sensitive to VRC01 (IC < 25 ug/mL) but another was resistant. By comparing Env sequences of resistant and sensitive clones from each participant, we identified sites predicted to affect VRC01 neutralization and assessed the effect of their reversion in the VRC01-resistant clone on neutralization sensitivity.
View Article and Find Full Text PDFJ Gastrointest Oncol
December 2024
Department of Intervention, Yancheng First People's Hospital, Yancheng, China.
Background: Hepatocellular carcinoma (HCC) is characterized by high postoperative recurrence rates, and predicting early recurrence is crucial for improving clinical outcomes, yet remains challenging. Both preoperative computed tomography (CT) imaging radiomic features and serum biomarkers related to microvascular infiltration are important indicators of HCC prognosis. This study aimed to develop a nomogram model incorporating both preoperative CT radiomic features and serum biomarkers associated with microvascular infiltration to predict early postoperative recurrence in HCC patients.
View Article and Find Full Text PDFAnn Ital Chir
January 2025
Department of Obstetrics and Gynecology, Center for Reproductive Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, 322000 Yiwu, Zhejiang, China.
Aim: This study aimed to explore influencing factors and develop a predictive model of endometrial polyps (EP) recurrence after hysteroscopic resection.
Methods: This retrospective study included 180 patients who underwent hysteroscopic resection for EP between January 2021 to December 2023. The patients were divided into a modeling group (n = 135) and a validation group (n = 45) in a 3:1 ratio.
Aim Of The Study: This study investigated the mechanism by which the Postoperative Tongqi Formula (PTQF) treats postoperative ileus (POI) through regulation of the p38 MAPK signaling pathway, Zona occludens 1 (ZO-1) protein, and metabolism.
Methods: The primary components of PTQF were characterized using UHPLC-Q-TOF-MS/MS. The identified compounds subsequently employed network pharmacology to predict the signaling pathways associated with the inflammatory phase of POI.
J Diabetes Res
January 2025
Section II of Endocrinology & Nephropathy Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Shenlian (SL) decoction, a renowned traditional Chinese formula for diabetes mellitus, has also been employed to treat intestinal disorders. Previous studies have demonstrated the efficacy of SL decoction in regulating blood glucose and intestinal bacteria. Nevertheless, further analysis is required to elucidate the mechanistic link between SL decoction-mediated improvement of intestinal function and treatment of Type 2 diabetes mellitus (T2DM).
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