[Purpose] We examined the incidence of cachexia at the beginning of rehabilitation in patients with advanced gastrointestinal cancer. [Participants and Methods] Patients with gastrointestinal cancer who were prescribed physical therapy and occupational therapy by their rehabilitation doctor and completed the survey item were targeted. We administered the cancer cachexia assessment and evaluated activities of daily living, and nutritional status in all participants. [Results] There were 15 patients in the normal group, 8 in the normal low-nutrition group, 16 in the pre-cachexia group, and 57 in the cachexia group. The cachexia group showed significantly lower nutritional status, and were less able to perform activities of daily living than the normal and pre-cachexia groups. [Conclusion] The incidence of cachexia among study participants was 17% in the pre-cachexia group and 59% in the cachexia group at the beginning of rehabilitation. Patients with advanced gastrointestinal cancer may have a higher incidence of cachexia at the beginning of rehabilitation.
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http://dx.doi.org/10.1589/jpts.32.16 | DOI Listing |
In Vivo
December 2024
Department of Practical Pharmacy, Nihon Pharmaceutical University, Saitama, Japan
Background/aim: Cancer cachexia is characterized by weight loss with a specific decrease in skeletal muscle and adipose tissue. In Japan, anamorelin, which has a novel mechanism of action, was approved in 2021 for the treatment of cancer cachexia. However, little information is available on its safety in routine clinical care, in particular the occurrence of conduction defects as adverse reactions.
View Article and Find Full Text PDFJ Cachexia Sarcopenia Muscle
February 2025
Chronic Disease Research Institute, the Children's Hospital, and National Clinical Research Center for Child Health, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, China.
Background: Normal weight obesity (NWO) is characterized by excess body fat in individuals with normal body mass index (BMI). This study aimed to investigate gut microbiota alterations in NWO and their potential associations with cardiometabolic diseases (CMD) risk in two independent cohorts.
Methods: Our NWO-CMD mortality analysis included 168 099 adults with normal BMI from two large open-access databases, while our NWO-gut microbiota study involved 5467 adults with normal BMI from two independent cohorts: the WELL-China cohort and the Lanxi cohort.
J Cachexia Sarcopenia Muscle
February 2025
Clinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK.
Support Care Cancer
December 2024
Department of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, 90127, Palermo, Italy.
J Pharm Health Care Sci
December 2024
Department of Pharmacy, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan.
Adverse events (AEs) induced by cancer chemotherapy reduce not only patient quality of life (QOL) but also the efficacy of treatment. Management of AEs can therefore improve both the efficacy and safety of cancer chemotherapy. This review describes the contribution of pharmacists to the management of adverse events aimed at improving the treatment efficacy of cancer chemotherapy.
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