AI Article Synopsis

  • Researchers developed a ceramide-coassembled lipid nanovehicle (CLNV) to improve the delivery of active ingredients through the skin barrier by leveraging the natural association between ceramides and lipids in the outer skin layer.
  • The CLNVs were created using a unique combination of lipids and cholesterol, demonstrating stability even under challenging conditions like high temperatures and salinity.
  • The study found that the CLNVs not only helped restore the skin's structural integrity after damage but also significantly enhanced the penetration of substances through the skin, indicating potential for use in pharmaceuticals and cosmetics.

Article Abstract

Herein, we report on a ceramide-coassembled lipid nanovehicle (CLNV) system that can enhance the penetration of active ingredients through the skin barrier by taking advantage of molecular associations between ceramide and lipids in the stratum corneum (SC) layer. For this purpose, we fabricated CLNVs consisting of an asymmetric lipid and a cholesterol derivative. They showed excellent long-term dispersion stability without molecular crystallization of ceramide. Upon forming a stable aqueous dispersion, the CLNVs retained their initial vehicle structure even under harsh conditions including high storage temperatures or salinity conditions. From in vitro skin barrier recovery tests, we observed that topical treatment with CLNVs induced the SC to restore its lamellar structure to the same condition as that prior to chemical damage. An in vivo skin penetration study additionally confirmed that skin penetration was enhanced, since the CLNVs were able to effectively interact with the SC layer. From these results, the CLNVs with robust molecular layer endow various applications in wide range applications including transdermal pharmaceutics delivery systems and cosmetics field.

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Source
http://dx.doi.org/10.1016/j.ijpharm.2020.119162DOI Listing

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