A new bilobalide isomer and two cis-coumaroylated flavonol glycosides from Ginkgo biloba leaves.

Fitoterapia

School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750004, PR China; State Key Lab. of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, PR China; School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China. Electronic address:

Published: April 2020

A new bilobalide isomer (1), together with two flavonol glycosides (2, 3), have been isolated and elucidated from the extract of Ginkgo biloba leaves. Significantly, 1 was a new sesquiterpene lactone with two lactone ring groups, both 2 and 3 were two flavonol glycosides with a same cis-coumaroylated fragment. Their chemical structures were elucidated by NMR and MS spectroscopic date and the absolute configuration of 1 was specific established by Cu-Kα X-ray crystallographic analyses. However, 1-3 showed no obvious anti-platelet aggregation activity.

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http://dx.doi.org/10.1016/j.fitote.2020.104516DOI Listing

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