One new long-chain ester derivative of trans-ferulic acid and one natural tirucallane-type triterpenoid , together with forty known compounds (), were isolated from the barks of . Their structures were established on the basis of spectroscopic data interpretation. Compounds , , , , showed significant inhibitory activities against PTP1B with IC values of 13.82 ± 1.29 μM, 13.29 ± 2.26 μM, 20.27 ± 0.52 μM, 24.36 ± 1.25 μM, 15.23 ± 0.6 μM, respectively.
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http://dx.doi.org/10.1080/14786419.2020.1729146 | DOI Listing |
Immunol Rev
December 2024
Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
αβT cells protect vertebrates against many diseases, optimizing surveillance using mechanical force to distinguish between pathophysiologic cellular alterations and normal self-constituents. The multi-subunit αβT-cell receptor (TCR) operates outside of thermal equilibrium, harvesting energy via physical forces generated by T-cell motility and actin-myosin machinery. When a peptide-bound major histocompatibility complex molecule (pMHC) on an antigen presenting cell is ligated, the αβTCR on the T cell leverages force to form a catch bond, prolonging bond lifetime, and enhancing antigen discrimination.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China. Electronic address:
In this paper, Mg/Al-layered double hydroxide (Mg/Al-LDH) was modified with the natural polymers sodium alginate and guar gum, and the prepared GG/SA/Mg-Al-LDH composite microsphere adsorbent (G-LDH) showed better adsorption performance for Congo red and hexavalent chromium in aqueous solution than the Mg/Al-LDH. The adsorption and surface properties of G-LDH in terms of functional groups, basic constituent elements and structural properties were obtained by different techniques. SEM shows that the average particle size of G-LDH is between 400 and 900 nm and exhibits a distinct microsphere morphology.
View Article and Find Full Text PDFDrug Des Devel Ther
January 2025
Clinical Medical College, Hubei University of Science and Technology, Xianning, People's Republic of China.
Purpose: Triple-negative breast cancer (TNBC) is a disease associated with high incidence and high mortality, which is a major problem threatening women's health. Xiaoyao Sanjie Decoction (XYSJD) exhibits remarkable therapeutic efficacy on TNBC; however, the underlying mechanism is unclear. This study verified the efficacy of XYSJD and its active component in the treatment of TNBC and explored its potential mechanism.
View Article and Find Full Text PDFPhytomedicine
November 2024
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China. Electronic address:
Background: Cinnamomum cassia Presl (Lauraceae) is widely used as a medicinal plant in the folk medicine and pharmaceutic industry, for its promising anti-inflammatory, anti-oxidative, and anti-bacterial function. However, the major bioactive components were still in debate, and their underlying molecular mechanism was not yet fully understood.
Purpose: This study aimed to identify the bioactive ingredients of C.
Phytomedicine
December 2024
School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, PR China; College of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, PR China; Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine, Shaanxi Administration of Traditional Chinese Medicine, Xi'an 712046, PR China; Shaanxi Key Laboratory of Research and Application of"Taibai Qi Yao", Xianyang 712046, PR China. Electronic address:
Background: Southern Schisandra is the dried and matured fruit of Schisandra sphenanthera Rehd. et Wils. in the family of Magnoliaceae; Traditional medicine reports that Schisandra sphenanthera has astringent and astringent properties, benefiting qi and promoting the production of body fluid, tranquilising the heart and calming the mind; it is clinically utilized for prolonged cough, thirst due to injury of the body fluid, internal heat and thirst, palpitation and insomnia, etc.
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