Objectives: Most of cardiac dedicated CZT-SPECT systems are not equipped with CT, whereas PET systems are. We evaluated the impact of AC correction on CZT-SPECT myocardial blood flow (MBF) and myocardial flow reserve (MFR) measurements.
Methods: 104 patients were included. SPECT data were acquired on cadmium zinc telluride (CZT)-based pinhole cardiac camera in listmode using a stress (250 ± 17 MBq)/rest (511 ± 23 MBq) 1-day Tc-99m-tetrofosmin protocol. Low-dose CT was acquired on another SPECT/CT camera in the same position. All analysis was performed using Corridor4DM.
Results: Stress and rest MBF were significantly lower when AC was applied (P < 0.001). For regional and global MFR, there was no significant difference between AC and NAC measurements (P > 0.25 at least). Mean global LV MFR was 2.43 ± 0.87 and 2.33 ± 0.89, respectively, for NAC and AC measurements. Using a threshold of 2, 86 patients (83%) remained classified as normal and abnormal regarding global LV MFR whether AC was applied or not. Mean difference between NAC and AC values for the 18 other patients was 0.3.
Conclusion: AC correction does not significantly affect MFR measurement both in regional and global LV analyses.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12350-020-02075-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Predictive Diagnostic Power of Anthropometric Indicators for Metabolic Syndrome: A Comparative Study in Korean Adults.
J Clin Med
January 2025
School of Global Sport Studies, Korea University, 2511, Sejong-ro, Sejong-si 30019, Republic of Korea.
Metabolic syndrome (MetS) is a cluster of risk factors that significantly increase the risk of cardiovascular disease, including type 2 diabetes, etc. Assessing the predictive diagnostic power of anthropometric indicators for MetS is crucial for the early identification and prevention of related health issues. This study focuses on the Korean adult population while providing insights that may be applicable to broader global contexts.
View Article and Find Full Text PDFCardiotoxicity as important differential diagnosis for reduced myocardial blood flow during Rubidium cardiac PET/CT : Cardiotoxicity in Rubidium PET/CT.
Int J Cardiovasc Imaging
January 2025
Department of Nuclear Medicine, Cantonal Hospital Baden, Partner Hospital for Research and Teaching of the Medical Faculty of the University of Zurich, Baden, 5404, Switzerland.
A 65-year-old woman with a history of ductal mammary carcinoma and recent autonomic dysfunction underwent a Rb-82 chloride (RbCl) cardiac PET/CT scan that showed no ischemia or scarring, but significantly reduced myocardial flow reserve (MFR) (global: 1.5) and a CAC-Score of 0. The patient's chemotherapy history (paclitaxel, carboplatin, epirubicin, pembrolizumab 2 years before) with elevated Troponin T and NT-pro-BNP levels at that time, and now reduced MFR with 0 CAC suggests cancer-therapy-related cardiotoxicity.
View Article and Find Full Text PDFUsefulness of dynamic perfusion SPECT with quantitative assessment of myocardial perfusion reserve for the detection of myocardial ischaemia in patients with presumed new left bundle branch block.
Eur Heart J Imaging Methods Pract
July 2024
Department of Nuclear Medicine, CHU de Caen Normandie, Normandie Univ, UNICAEN UR 4650 PSIR, Avenue Cote de Nacre, 14000 Caen, France.
Article Synopsis
- The study aimed to assess how well dynamic SPECT with quantitative analysis of myocardial blood flow (MBF) and myocardial flow reserve (MFR) can detect coronary artery disease (CAD) in patients with new left bundle branch block (LBBB).
- The evaluation involved 174 patients with LBBB, finding SPECT abnormalities in only a small percentage, and highlighting a correlation between reduced MFR and fixed defects, although only a few patients had significant CAD after further examination.
- The conclusion suggests that routine screening for CAD in patients with presumed new LBBB may not be necessary, given the low incidence of actual CAD found.
Emotional competence self-help mobile phone app versus cognitive behavioural self-help app versus self-monitoring app to promote mental wellbeing in healthy young adults (ECoWeB PROMOTE): an international, multicentre, parallel, open-label, randomised controlled trial.
Lancet Digit Health
December 2024
Medical Research Council/Chief Scientist Office Social and Public Health Sciences Unit, School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Article Synopsis
- The study investigates the effectiveness of three different self-help apps aimed at improving mental wellbeing among young people, specifically comparing a personalised emotional competence app, a cognitive behavioural therapy (CBT) app, and a self-monitoring app.
- Conducted as a randomised controlled trial across four countries, the research involved 2532 young participants aged 16-22 without major depression, who were monitored for 12 months to assess changes in mental wellbeing.
- The primary measurement for evaluating success was the Warwick-Edinburgh Mental Well Being Scale (WEMWBS) at a 3-month follow-up, ensuring that the outcomes were objectively assessed by unaware evaluators.
CXCL9/CXCL10 as biomarkers the monitoring of treatment responses in Pulmonary TB patients: a systematic review and meta-analysis.
BMC Infect Dis
September 2024
State Key Laboratory of Respiratory Disease, Guangzhou Key Laboratory of Tuberculosis Research, Institute of Pulmonary Diseases, Guangzhou Chest Hospital, Institute of Tuberculosis, Guangzhou Medical University, 62 Hengzhigang Rd, Yuexiu District, Guangzhou, 510095, People's Republic of China.
Background: Tuberculosis (TB) remains a persistent threat to global public health and traditional treatment monitoring approaches are limited by their potential for contamination and need for timely evaluation. Therefore, new biomarkers are urgently required for monitoring the treatment efficacy of TB.
Methods: This study aimed to elucidate the levels of CXCL10 and CXCL9 in pulmonary TB patients who underwent anti-TB treatment.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!