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Interleukin-38-overexpressing adenovirus infection in dendritic cell-based treatment enhances immunotherapy for allergic asthma via inducing Foxp3 regulatory T cells.
Biomed Pharmacother
December 2024
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address:
Allergic asthma is a chronic disease tied to unusual immune reactions involving type 2 T helper (Th2) cells specific to allergens. Dendritic cells (DCs) play a crucial role in guiding T-cell responses. Regulatory T (Treg) cells have the ability to suppress effector T-cell responses, and interleukin (IL)-38 is involved in Treg cell differentiation.
View Article and Find Full Text PDFSystemic Epstein-Barr Virus-Positive T-Cell Lymphoma of Childhood Associated With t(1;22)(p22;q11.2) Mutation.
J Hematol
October 2024
Division of Hematology and Cellular Therapy, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.
Article Synopsis
- Systemic Epstein-Barr virus-positive T-cell lymphoma (TCL) in children is rare and often follows an EBV infection, leading to a hyperinflammatory state and poor outcomes, often presenting with hemophagocytic lymphohistiocytosis (HLH) syndrome.
- The disorder involves a hyperactive immune response and may be linked to genetic alterations on chromosome 22q11.2, increasing the risk of non-Hodgkin lymphoma later in life.
- A case study of a 21-year-old male who developed HLH from an EBV infection ultimately resulted in a diagnosis of systemic EBV TCL, and despite treatment, he did not survive before receiving a stem cell transplant, highlighting the need for awareness
Excessive cleavage of von Willebrand factor multimers by ADAMTS13 may predict the progression of transplant-associated thrombotic microangiopathy.
Res Pract Thromb Haemost
July 2024
Department of Blood Transfusion Medicine, Nara Medical University, Kashihara City, Nara, Japan.
Article Synopsis
- Transplant-associated thrombotic microangiopathy (TA-TMA) is a serious complication of hematopoietic stem cell transplants that causes severe blood-related issues and organ dysfunction due to small blood clots forming in circulation.
- This study examined changes in von Willebrand factor (VWF) in patients to understand its role in the development of TA-TMA, analyzing plasma samples from 14 patients post-transplant.
- Results indicated that patients with definite TMA showed unique VWF changes compared to those with probable TMA, highlighting a transition from bleeding risks to clotting tendencies based on VWF multimer profiles and degradation products.
Acute Coronary Syndrome as an Unusual Initial Presentation of T-Prolymphocytic Leukemia: A Case Report and Review of the Literature.
Case Rep Hematol
August 2024
Department of Oncology, Hematology, Immune-Oncology and Rheumatology University Hospital Bonn, Bonn, Germany.
T-prolymphocytic leukaemia (T-PLL) is the most common mature T-cell leukaemia in Central Europe and is often manifested by rapidly increasing lymphocytosis, marked bone marrow infiltration and splenomegaly. In 10-15% of cases, the diagnosis is made by incidental findings in otherwise asymptomatic patients. Here we report a case of T-PLL that initially became symptomatic due to the presence of acute coronary syndrome (ACS).
View Article and Find Full Text PDFDisseminated Mucormycosis and T-Cell-Depleted Allogeneic Stem Cell Transplantation: An Unusual Case Study.
Acta Haematol
August 2024
Department of Haematology, King's College Hospital, London, UK.
Introduction: Invasive fungal infections are a primary cause of morbidity and mortality in patients with haematological malignancies.
Case Presentation: We describe an unusual clinical and radiological presentation of invasive mucormycosis (IM) in a 69-year-old patient with relapsed acute myeloid leukaemia. The patient was diagnosed with disseminated IM with involvement of the central nervous system in an atypical location, lung, spleen, muscle, bone, and heart, after having completed induction and bridging chemotherapy to allogeneic haematopoietic stem cell transplant (HSCT).
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